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Signal transduction: How cells sense energy.

作者信息

Hardie D Grahame

出版信息

Nature. 2011 Apr 14;472(7342):176-7. doi: 10.1038/472176a.

DOI:10.1038/472176a
PMID:21490664
Abstract
摘要

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1
Signal transduction: How cells sense energy.信号转导：细胞如何感知能量。
Nature. 2011 Apr 14;472(7342):176-7. doi: 10.1038/472176a.
2
Structure of mammalian AMPK and its regulation by ADP.哺乳动物 AMPK 的结构及其被 ADP 调节。
Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.
3
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation.AMP 通过别构激活和增强净磷酸化来作为 AMP 激活的蛋白激酶的真正生理调节剂。
Cell Metab. 2013 Oct 1;18(4):556-66. doi: 10.1016/j.cmet.2013.08.019.
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Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.用于测量调节性配体对AMPK作用的无细胞分析
Methods Mol Biol. 2018;1732:69-86. doi: 10.1007/978-1-4939-7598-3_5.
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Cell biology. ADaPting to energetic stress.细胞生物学。适应能量应激。
Science. 2011 Jun 17;332(6036):1387-8. doi: 10.1126/science.1208444.
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AMPK is a direct adenylate charge-regulated protein kinase.AMPK 是一种直接受腺嘌呤核苷酸调控的蛋白激酶。
Science. 2011 Jun 17;332(6036):1433-5. doi: 10.1126/science.1200094.
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Structural basis of AMPK regulation by adenine nucleotides and glycogen.腺嘌呤核苷酸和糖原对AMPK调节的结构基础
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AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand.AMP 激活的蛋白激酶可被 ADP 变构激活，但 AMP 仍然是关键的激活配体。
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The linkage between adenosine nucleotide binding and amidase activity in human alpha-thrombin.
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AMPK in myocardial infarction and diabetes: the yin/yang effect.腺苷酸活化蛋白激酶在心肌梗死和糖尿病中的作用：阴阳效应
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Plasmodium Infection Induces Dyslipidemia and a Hepatic Lipogenic State in the Host through the Inhibition of the AMPK-ACC Pathway.疟原虫感染通过抑制 AMPK-ACC 通路诱导宿主血脂异常和肝脏脂肪生成状态。
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Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease.

本文引用的文献

1
Structure of mammalian AMPK and its regulation by ADP.哺乳动物 AMPK 的结构及其被 ADP 调节。
Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.
2
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).β-亚基豆蔻酰化是 AMP 激活的蛋白激酶（AMPK）启动代谢应激感应的守门员。
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41. doi: 10.1073/pnas.1009705107. Epub 2010 Oct 25.
3
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase.
水通道蛋白-3 缺乏可减缓常染色体显性多囊肾病实验小鼠模型中的囊肿增大。
FASEB J. 2019 May;33(5):6185-6196. doi: 10.1096/fj.201801338RRR. Epub 2019 Feb 15.
4
AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation-associated AMPKα1 activation.AMPKα2 基因敲除通过加剧肝损伤和与能量耗竭相关的 AMPKα1 激活增强肿瘤炎症。
J Cell Mol Med. 2019 Mar;23(3):1687-1697. doi: 10.1111/jcmm.13978. Epub 2019 Jan 12.
5
1,25-Dihydroxyvitamin D inhibits the proliferation of rat mesangial cells induced by high glucose via DDIT4.1,25-二羟基维生素D通过DDIT4抑制高糖诱导的大鼠系膜细胞增殖。
Oncotarget. 2017 Dec 9;9(1):418-427. doi: 10.18632/oncotarget.23063. eCollection 2018 Jan 2.
6
Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death.CD8 + T细胞中AMPK的缺乏通过诱导蛋白磷酸酶介导的细胞死亡来抑制其抗肿瘤功能。
Oncotarget. 2015 Apr 10;6(10):7944-58. doi: 10.18632/oncotarget.3501.
7
Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway.α-硫辛酸通过mTOR/p70S6K/4E-BP1信号通路调节高糖诱导的大鼠系膜细胞功能障碍
Int J Endocrinol. 2014;2014:658589. doi: 10.1155/2014/658589. Epub 2014 Oct 30.
8
On the dynamics of the adenylate energy system: homeorhesis vs homeostasis.论腺苷酸能量系统的动力学：动态平衡与稳态平衡
PLoS One. 2014 Oct 10;9(10):e108676. doi: 10.1371/journal.pone.0108676. eCollection 2014.
9
In silico design for adenosine monophosphate-activated protein kinase agonist from traditional chinese medicine for treatment of metabolic syndromes.基于代谢综合征治疗的中药腺苷单磷酸激活蛋白激酶激动剂的计算机辅助设计。
Evid Based Complement Alternat Med. 2014;2014:928589. doi: 10.1155/2014/928589. Epub 2014 May 11.
10
RNA mimicry by the fap7 adenylate kinase in ribosome biogenesis.在核糖体生物发生过程中，fap7腺苷酸激酶的RNA模拟作用
PLoS Biol. 2014 May 13;12(5):e1001860. doi: 10.1371/journal.pbio.1001860. eCollection 2014 May.
对AMP激活的蛋白激酶自抑制机制的结构洞察
Nature. 2009 Jun 25;459(7250):1146-9. doi: 10.1038/nature08075. Epub 2009 May 27.
4
Structural basis for AMP binding to mammalian AMP-activated protein kinase.AMP与哺乳动物AMP激活蛋白激酶结合的结构基础。
Nature. 2007 Sep 27;449(7161):496-500. doi: 10.1038/nature06161. Epub 2007 Sep 12.
5
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.AMP激活的/SNF1蛋白激酶：细胞能量的保守守护者。
Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85. doi: 10.1038/nrm2249.
6
Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase.剖析5'-AMP在变构刺激、激活和失活AMP激活的蛋白激酶中的作用。
J Biol Chem. 2006 Oct 27;281(43):32207-16. doi: 10.1074/jbc.M606357200. Epub 2006 Aug 30.
7
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations.CBS结构域形成能量感应模块，其与腺苷配体的结合会因疾病突变而被破坏。
J Clin Invest. 2004 Jan;113(2):274-84. doi: 10.1172/JCI19874.
8
5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.5'-腺苷酸抑制AMP活化蛋白激酶的去磷酸化作用，同时促进其磷酸化作用。研究使用了细菌表达的人蛋白磷酸酶-2Cα和天然牛蛋白磷酸酶-2AC。
FEBS Lett. 1995 Dec 27;377(3):421-5. doi: 10.1016/0014-5793(95)01368-7.
9
5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.5'-腺苷酸通过三种独立机制激活腺苷酸活化蛋白激酶级联反应，而钙离子/钙调蛋白则激活钙调蛋白依赖性蛋白激酶I级联反应。
J Biol Chem. 1995 Nov 10;270(45):27186-91. doi: 10.1074/jbc.270.45.27186.
10
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.AMP激活的蛋白激酶的纯化与特性分析。乙酰辅酶A羧化酶激酶和3-羟基-3-甲基戊二酰辅酶A还原酶激酶活性的共纯化。
Eur J Biochem. 1989 Dec 8;186(1-2):129-36. doi: 10.1111/j.1432-1033.1989.tb15186.x.