Temiye Edamisan Olusoji, Duke Edem Samuel, Owolabi Mbang Adeyemi, Renner James Kweku
Department of Paediatrics, College of Medicine, University of Lagos (CMUL), P.M.B 12003, Lagos, Nigeria.
Anemia. 2011;2011:698586. doi: 10.1155/2011/698586. Epub 2010 Nov 25.
Sickle cell anaemia (SCA) is associated with zinc deficiency; zinc supplementation may ameliorate some of its clinical manifestations including the relief of painful crisis. Subjects and Methods. Serum zinc levels were determined in 71 children with SCA and painful crisis and in equal numbers in steady state. Seventy-one children with AA genotype acted as controls. Qualitative assessment of zinc content of 24-hour dietary recall and the last meal consumed before blood was drawn was taken. Serum zinc was determined using atomic absorption spectrophotometer. Haemoglobin concentration and packed cell volume (PCV) were determined using standard methods. Results. The mean serum zinc concentration in the study was less than international reference range. The controls had significantly higher serum zinc concentrations than the SCA group (42.7 ± 13.6 versus 32.3 ± 14.0 μg/dL, P < .000); this difference was due to the significantly lower values of serum zinc in SCA with painful crisis compared with the remaining two groups F = 30.9, P<.000. There was a positive correlation between serum zinc and haemoglobin concentration only in the control group (r = 0.4; P = .001). Conclusion. The serum zinc levels in this study were low. Painful crisis in SCA may exert greater demand for zinc utilization in children with SCA thereby resulting in lower serum levels.
镰状细胞贫血（SCA）与锌缺乏有关；补充锌可能会改善其一些临床表现，包括缓解疼痛性危象。对象与方法。测定了71例患有SCA且处于疼痛性危象的儿童以及同等数量处于稳定期的儿童的血清锌水平。71例基因型为AA的儿童作为对照。对24小时饮食回忆和采血前最后一餐的锌含量进行了定性评估。使用原子吸收分光光度计测定血清锌。使用标准方法测定血红蛋白浓度和红细胞压积（PCV）。结果。研究中的平均血清锌浓度低于国际参考范围。对照组的血清锌浓度显著高于SCA组（42.7±13.6对32.3±14.0μg/dL，P<.000）；这种差异是由于与其余两组相比，处于疼痛性危象的SCA患者血清锌值显著较低（F=30.9，P<.000）。仅在对照组中血清锌与血红蛋白浓度呈正相关（r=0.4；P=.001）。结论。本研究中血清锌水平较低。SCA中的疼痛性危象可能会使患有SCA的儿童对锌的利用需求更大，从而导致血清水平较低。
