Ganguly A, Boswell W, Aniq H
Department of Radiology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK.
Anemia. 2011;2011:794283. doi: 10.1155/2011/794283. Epub 2011 Feb 6.
Sickle cell anaemia is an autosomal recessive genetic condition producing abnormal haemoglobin HbS molecules that result in stiff and sticky red blood cells leading to unpredictable episodes of microvascular occlusions. The clinical and radiological manifestations of sickle cell anaemia result from small vessel occlusion, leading to tissue ischemia/infarction and progressive end-organ damage. In this paper we discuss and illustrate the various musculoskeletal manifestations of sickle cell disease focusing primarily on marrow hyperplasia, osteomyelitis and septic arthritis, medullary and epiphyseal bone infarcts, growth defects, and soft tissue changes.
镰状细胞贫血是一种常染色体隐性遗传疾病，会产生异常的血红蛋白HbS分子，导致红细胞僵硬且黏附性增强，从而引发不可预测的微血管闭塞发作。镰状细胞贫血的临床和放射学表现是由小血管闭塞引起的，会导致组织缺血/梗死以及终末器官的进行性损害。在本文中，我们将讨论并举例说明镰状细胞病的各种肌肉骨骼表现，主要聚焦于骨髓增生、骨髓炎和化脓性关节炎、骨髓和骨骺骨梗死、生长缺陷以及软组织变化。
