Mori Akihiro, Lee Peter, Yokoyama Takeshi, Oda Hitomi, Saeki Kaori, Miki Yohei, Nozawa Satoshi, Azakami Daigo, Momota Yutaka, Makino Yuki, Matsubara Takako, Osaka Motohisa, Ishioka Katsumi, Arai Toshiro, Sako Toshinori
School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, Japan.
J Artif Organs. 2011 Jun;14(2):133-9. doi: 10.1007/s10047-011-0560-1. Epub 2011 Apr 14.
Artificial pancreas technology, involving "closed-loop" controls with real-time blood glucose monitoring, has been increasing in reliability as its potential for clinical use and application grows. One such device, based on this technology, is the STG-22 (Nikkiso Co., Ltd., Tokyo, Japan) artificial pancreas apparatus. In order to assess the reliability and accuracy of the device for measuring blood glucose, it is important to compare its readings to those obtained using a 'gold standard' method, such as the hexokinase method. Therefore, in the present study, canine blood [glucose] measurements using the STG-22 were compared to those obtained using a previously established commercial reagent, Quickauto-Neo GLU-HK. Furthermore, two different sample types (whole blood versus plasma constituent) were compared to determine which sample type results in more accurate and optimal readings with the STG-22. Given that the STG-22 was not primarily designed for canine blood samples, results for canine blood samples were not accurate. Measurements performed by the STG-22 with whole blood were significantly lower than reference [glucose] counterparts. Alternatively, an opposite trend was observed with plasma measurements that were significantly higher. A conversion format using the following formula, Hexokinase [glucose] = STG-22 [glucose] × 1.407 + 1.532, was observed with canine samples in our study.
人工胰腺技术，包括带有实时血糖监测的“闭环”控制，随着其临床应用潜力的增加，可靠性也在不断提高。基于这项技术的一种设备是STG-22（日本东京日机装株式会社）人工胰腺装置。为了评估该设备测量血糖的可靠性和准确性，将其读数与使用“金标准”方法（如己糖激酶法）获得的读数进行比较很重要。因此，在本研究中，将使用STG-22对犬类血液[葡萄糖]的测量结果与使用先前建立的商业试剂Quickauto-Neo GLU-HK获得的测量结果进行了比较。此外，还比较了两种不同的样本类型（全血与血浆成分），以确定哪种样本类型使用STG-22能得出更准确和最佳的读数。鉴于STG-22并非主要为犬类血液样本设计，犬类血液样本的结果并不准确。STG-22对全血进行的测量显著低于对照[葡萄糖]对应值。相反，血浆测量结果则呈现相反趋势，显著更高。在我们的研究中，犬类样本观察到使用以下公式的转换形式：己糖激酶[葡萄糖]=STG-22[葡萄糖]×1.407 + 1.532。
