Department of Veterinary Nursing and Technology, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8602, Japan.
Res Vet Sci. 2011 Jun;90(3):396-403. doi: 10.1016/j.rvsc.2010.07.001. Epub 2010 Aug 12.
Insulin detemir is the first member of a new class of long-acting soluble insulin analogues capable of maintaining the basal level of insulin in humans. In this preliminary study, we investigated the time-action profiles of insulin detemir in normal and diabetic dogs since the use of insulin detemir in canines has yet to be determined. Eight animals were used in our study (three normal and five insulin dependent diabetic dogs). Time-action profiles of insulin detemir were monitored in normal dogs using an artificial pancreas apparatus under euglycemic condition. Blood sampling was performed at 2h intervals post feeding, with insulin administration, in insulin dependent diabetic dogs. Time-action profiles of insulin detemir, in normal dogs, demonstrated that insulin detemir is a long-lasting preparation similar to what has been observed in humans. A pronounced peak was detected at 8-10h while the glucose-lowering effect lasted for over 24h after insulin injection, thus illustrating its longer prolonged peak activity time. Furthermore, intensive glycemic control was achieved with insulin detemir in insulin dependent diabetic dogs, using a lower dosage than NPH insulin and insulin glargine therapeutic doses. Our results indicate that insulin detemir has a greater effect than either NPH insulin or insulin glargine in canines, requiring a lower dose than either insulin preparation. However, using insulin detemir also carries a higher risk of inducing hypoglycemia as compared to either NPH insulin or insulin glargine.
胰岛素地特胰岛素是新型长效可溶性胰岛素类似物中的第一个成员，能够维持人类的基础胰岛素水平。在这项初步研究中，我们研究了胰岛素地特胰岛素在正常和糖尿病犬中的时间-作用曲线，因为尚未确定在犬中使用胰岛素地特胰岛素。我们的研究使用了 8 只动物（3 只正常和 5 只胰岛素依赖型糖尿病犬）。在正常犬中，使用人工胰腺装置在血糖正常的情况下监测胰岛素地特胰岛素的时间-作用曲线。在胰岛素依赖型糖尿病犬中，在喂食后 2 小时间隔进行采血，并给予胰岛素。在正常犬中，胰岛素地特胰岛素的时间-作用曲线表明，胰岛素地特胰岛素是一种长效制剂，与在人类中观察到的情况相似。在 8-10 小时时检测到明显的峰值，而在注射胰岛素后，其降血糖作用持续超过 24 小时，因此表明其延长的峰值活性时间更长。此外，与 NPH 胰岛素和甘精胰岛素治疗剂量相比，在胰岛素依赖型糖尿病犬中使用胰岛素地特胰岛素可以实现更密集的血糖控制，所需剂量低于 NPH 胰岛素或甘精胰岛素。我们的结果表明，与 NPH 胰岛素或甘精胰岛素相比，胰岛素地特胰岛素在犬中具有更大的作用，所需剂量低于这两种胰岛素制剂。然而，与 NPH 胰岛素或甘精胰岛素相比，使用胰岛素地特胰岛素也会增加低血糖的风险。
