Li Zhiwei, Xiao Kaibing, Niu Shaorui, Zhu Qiqi, Xiao Zhiyang, Yang Pang
Department of Urology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China.
Department of Intensive Care Unit, The First People's Hospital of Guangyuan, Guangyuan, China.
Heliyon. 2024 Oct 2;10(19):e38807. doi: 10.1016/j.heliyon.2024.e38807. eCollection 2024 Oct 15.
Primary synovial sarcoma originating in the pelvis is an extremely rare malignancy, and only a few cases have been reported. Usually, the tumor is detected at an advanced stage, making treatment more difficult. Lacking high-quality research, there are no consensus guidelines for the systemic treatment of the disease.
We admitted a 32-year-old male patient with an MRI suggestive of an 8.2 × 7.7 x 8.9 cm mass in the pelvis with bleeding. After a comprehensive evaluation, the patient underwent surgery, and postoperative pathology suggested biphasic synovial sarcoma. Once the diagnosis was clear, the patient was treated with chemotherapy, radiotherapy, and targeted therapy. Unfortunately, the patient died due to a recurrence of pelvic synovial sarcoma with multiple metastases throughout the body, with a survival period of 28 months.
Synovial sarcoma, a highly malignant soft tissue tumor, and primary intrapelvic synovial sarcoma are even rarer, with a poor prognosis. Ultrasound, Computed Tomography, and MRI can help doctors detect the tumor at an early stage and treat it aggressively, especially with surgical treatment, which can effectively improve the survival rate. Combined with the course of diagnosis and treatment of this case, it is possible to deepen the understanding of primary pelvic synovial sarcoma and discuss appropriate treatment strategies for this rare disease.
原发性骨盆滑膜肉瘤是一种极为罕见的恶性肿瘤，仅有少数病例报道。通常，肿瘤在晚期才被发现，这使得治疗更加困难。由于缺乏高质量研究，对于该疾病的全身治疗尚无共识性指南。
我们收治了一名32岁男性患者，其磁共振成像（MRI）显示骨盆有一个8.2×7.7×8.9厘米的肿物且伴有出血。经过全面评估，患者接受了手术，术后病理提示为双相型滑膜肉瘤。确诊后，患者接受了化疗、放疗及靶向治疗。不幸的是，患者因骨盆滑膜肉瘤复发并全身多处转移而死亡，生存期为28个月。
滑膜肉瘤是一种高度恶性的软组织肿瘤，而原发性骨盆内滑膜肉瘤更为罕见，预后较差。超声、计算机断层扫描（CT）和MRI有助于医生早期发现肿瘤并积极进行治疗，尤其是手术治疗，可有效提高生存率。结合该病例的诊治过程，有助于加深对原发性骨盆滑膜肉瘤的认识，并探讨针对这种罕见疾病的合适治疗策略。
