Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, Department of Microbiology, 75015 Paris, France.
Appl Microbiol Biotechnol. 2011 May;90(3):851-9. doi: 10.1007/s00253-011-3227-1. Epub 2011 Mar 29.
Antibiotic-resistant bacteria are an increasing source of concern in all environments in which these drugs have been used. More stringent regulations have led to a slow but sure decrease in antibiotic use in the food industry worldwide, but have also stimulated the search for alternative antibacterial agents. In medicine, the number of people infected with pan-resistant bacteria is driving research to develop new treatments. Within these contexts, studies on the use of bacteriophages in both medicine and the food industry have recently flourished. This renewed interest has coincided with the demonstration that these viruses are involved in geochemical cycles, revolutionizing our vision of their ecological role on our planet. Bacteriophages have co-evolved with bacteria for billions of years and retain the ability to infect bacteria efficiently. They are undoubtedly one of the best potential sources of new solutions for the management of undesirable bacteria.
在所有使用过这些药物的环境中，抗生素耐药菌都是一个日益令人担忧的问题。更严格的规定导致全球范围内食品行业的抗生素使用量缓慢但稳步下降，但也刺激了对替代抗菌药物的寻找。在医学领域，感染泛耐药菌的人数正在推动人们研发新的治疗方法。在这些背景下，医学和食品工业中噬菌体的使用研究最近蓬勃发展。这种新的兴趣与证明这些病毒参与地球化学循环同时出现，彻底改变了我们对它们在我们星球上生态作用的看法。噬菌体与细菌共同进化了数十亿年，仍然能够有效地感染细菌。它们无疑是管理不良细菌的新解决方案的最佳潜在来源之一。
