McCarthy J E
Department of Microbiology, GBF-Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.
Mol Microbiol. 1990 Aug;4(8):1233-40. doi: 10.1111/j.1365-2958.1990.tb00702.x.
Post-transcriptional control mechanisms assume special significance in polycistronic operons. Differential gene expression in the atp operon of Escherichia coli is primarily attributable to translational control and, to a lesser extent, to control of mRNA stability. At the same time, the polycistronic environment influences, to varying degrees, the relative importance of the different types of post-transcriptional control. The present article briefly reviews more recent results obtained through studies of the atp operon. Investigations of the pathway and kinetics of mRNA decay have yielded new information about the role of degradative mechanisms in the overall scheme of control. Moreover, translational coupling has been shown to feature as a major form of interaction between the atp genes. The relevance of these and other data is discussed in the wider context of the post-transcriptional control mechanisms generally available to E. coli.
转录后调控机制在多顺反子操纵子中具有特殊的重要性。大肠杆菌atp操纵子中的差异基因表达主要归因于翻译调控，在较小程度上也归因于mRNA稳定性的调控。同时，多顺反子环境在不同程度上影响了不同类型转录后调控的相对重要性。本文简要回顾了通过对atp操纵子研究获得的最新结果。对mRNA衰变途径和动力学的研究产生了关于降解机制在整体调控方案中作用的新信息。此外，翻译偶联已被证明是atp基因之间相互作用的主要形式。在大肠杆菌普遍存在的转录后调控机制的更广泛背景下，讨论了这些及其他数据的相关性。
