细胞特异性肽修饰多糖纳米凝胶用于蛋白质递送。
Cell specific peptide-conjugated polysaccharide nanogels for protein delivery.
机构信息
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
出版信息
Macromol Biosci. 2011 Jul 7;11(7):882-8. doi: 10.1002/mabi.201000491. Epub 2011 Apr 13.
A cell specific peptide (Arg-Gly-Asp; RGD)-modified nanogel was prepared and evaluated for its potential to act as a protein delivery carrier. A bovine serum albumin (BSA)/RGD-modified nanogel complex was efficiently internalized into cells through integrin-mediated endocytosis. Endosomal escape of the RGD-modified nanogel was observed after 24 h incubation. The nanogel proved useful for targeted protein delivery.
一种细胞特异性肽（精氨酸-甘氨酸-天冬氨酸；RGD）修饰的纳米凝胶被制备并评估其作为蛋白质递送载体的潜力。牛血清白蛋白（BSA）/RGD 修饰的纳米凝胶复合物通过整联蛋白介导的内吞作用有效地被细胞内化。在孵育 24 小时后，观察到 RGD 修饰的纳米凝胶的内涵体逃逸。该纳米凝胶可用于靶向蛋白质递送。
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