Department of Diagnostic Medical Sciences and Special Therapies, Surgical Pathology and Cytopathology Unit, University of Padua, Padua, Italy.
Cancer Cytopathol. 2011 Apr 25;119(2):134-40. doi: 10.1002/cncy.20132. Epub 2010 Dec 17.
In pediatric patients, a cutaneous nodule is usually diagnosed by performing an excisional biopsy, but fine-needle cytology (FNC) is a safer and noninvasive diagnostic method widely used to obtain diagnostic specimens with little stress to the patient. The authors compared the ability of FNC and biopsy to differentiate Langerhans cell histiocytosis (LCH) from juvenile xanthogranuloma (JXG).
Correlating cytological results with histological findings, the authors reviewed 27 patients (15 males and 12 females; mean age, 37 months; range, 1 month to 14 years) admitted to the University of Padua Department of Pediatrics from 1998 to 2010.
Cytology smears were adequate in all 27 (100%) patients: 14 (52%) were classified as having JXG, 12 (44%) as having LCH, and 1 (4%) as having a doubtful finding. A biopsy was also performed in 20 of these patients, and in all but 1, the 2 methods were completely concordant.
FNC is safe and useful in the diagnostic workup of pediatric patients with cutaneous nodules and has no contraindications to its use as the initial diagnostic procedure.
在儿科患者中，皮肤结节通常通过进行切除活检来诊断，但细针细胞学（FNC）是一种更安全且非侵入性的诊断方法，广泛用于获取诊断标本，对患者的压力很小。作者比较了 FNC 和活检对鉴别朗格汉斯细胞组织细胞增生症（LCH）与幼年黄色肉芽肿（JXG）的能力。
作者通过细胞学结果与组织学发现的相关性，回顾了 1998 年至 2010 年期间在帕多瓦大学儿科系就诊的 27 名患者（15 名男性和 12 名女性；平均年龄 37 个月；范围 1 个月至 14 岁）。
所有 27 名患者的细胞学涂片均足够（100%）：14 名（52%）归类为 JXG，12 名（44%）归类为 LCH，1 名（4%）归类为可疑发现。其中 20 名患者还进行了活检，除 1 例外，这两种方法完全一致。
FNC 是一种安全且有用的方法，可用于儿科患者皮肤结节的诊断评估，并且没有使用它作为初始诊断程序的禁忌症。
