Department of Pathology, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece.
Brain Pathol. 2011 May;21(3):351-4. doi: 10.1111/j.1750-3639.2011.00483.x.
A 57-year-old female presented with recurrent episodes of nausea and vomit, as well as instability during walking. The patient had a history of uterine leiomyosarcoma, for which she underwent a hysterectomy and oophorectomy 8 months ago. CT scan revealed a calcified mass that was located in the left cerebellar hemisphere which was resected. Histologically, multiple tissue fragments displayed infiltration of cerebellar tissue by polymorphic spindle-shaped cells. The Ki-67 proliferation index was approximately 20%. The morphological and immunohistochemical data, in association with the past clinical history, were consistent with cerebellar metastasis of uterine leiomyosarcoma. Although adjuvant radiotherapy was introduced, the patient died of cardiopulmonary arrest 6 weeks after the surgical procedure. The present case adds to the body of literature being the second report of uterine leiomyosarcoma metastatic to the cerebellum.
一位 57 岁女性因反复恶心和呕吐以及行走时不稳定而就诊。该患者曾患有子宫平滑肌肉瘤，8 个月前接受了子宫切除术和卵巢切除术。CT 扫描显示一个钙化肿块位于左侧小脑半球，已被切除。组织学上，多个组织片段显示多形性梭形细胞浸润小脑组织。Ki-67 增殖指数约为 20%。形态学和免疫组织化学数据结合过去的临床病史，与子宫平滑肌肉瘤小脑转移一致。尽管辅助放疗，但该患者在手术后 6 周死于心肺骤停。本病例增加了文献报道，是第二个子宫平滑肌肉瘤转移至小脑的病例。
