España P, Chang P, Wiernik P H
Cancer. 1980 Jan 15;45(2):377-80. doi: 10.1002/1097-0142(19800115)45:2<377::aid-cncr2820450231>3.0.co;2-5.
Eleven cases of brain metastases that developed in 114 sarcoma patients are presented. Two of 11 patients presented with brain metastasis at the time of diagnosis and the other nine developed them later. The high incidence of brain metastases in patients with rhabdomyosarcoma (26%) and malignant fibrous histiocytoma (27%), two types of tumor which supposedly metastasize rarely to the brain, is remarkable. The increased incidence of brain metastases may be related to longer survival of sarcoma patients and to the inability of AMN and other drugs used in the treatment of sarcomas to cross the blood-brain barrier. Preventive treatment of brain metastases with drugs active in the CNS or with radiotherapy following the diagnosis of pulmonary metastases, could be useful, especially in patients with rhabdomyosarcoma and malignant fibrous histiocytoma.
本文报告了114例肉瘤患者中发生的11例脑转移病例。11例患者中有2例在诊断时即出现脑转移，另外9例后来发生脑转移。横纹肌肉瘤（26%）和恶性纤维组织细胞瘤（27%）这两种通常很少转移至脑的肿瘤类型，其患者脑转移的高发生率令人瞩目。脑转移发生率的增加可能与肉瘤患者生存期延长以及治疗肉瘤所用的氨甲蝶呤和其他药物无法穿过血脑屏障有关。在诊断出肺转移后，使用对中枢神经系统有活性的药物或放疗对脑转移进行预防性治疗可能会有帮助，尤其是对横纹肌肉瘤和恶性纤维组织细胞瘤患者。
