Noma A, Maeda S, Okuno M, Abe A, Muto Y
Department of Laboratory Medicine, Gifu University School of Medicine, Japan.
Atherosclerosis. 1990 Oct;84(2-3):213-7. doi: 10.1016/0021-9150(90)90093-x.
The effect of low dose (600 mg/day) alpha-tocopheryl nicotinate on serum lipoprotein(a) (Lp(a] concentration was studied in 28 hyperlipidaemic patients. Serum lipids, lipoproteins and apolipoproteins, except for Lp(a), tended to increase after treatment. In particular, the changes in HDL-cholesterol and apo C-II levels were statistically significant. On the other hand, serum Lp(a) levels in all patients decreased significantly after 2 months of treatment. Furthermore, no difference between before and after treatment was observed in the group with initial Lp(a) levels less than 18 mg/dl, whereas Lp(a) concentrations decreased significantly after treatment in the group with levels greater than or equal to 18 mg/dl. The effects of probucol and alpha-tocopheryl nicotinate on serum Lp(a), total cholesterol and HDL-cholesterol were entirely different. Possible mechanisms of alpha-tocopheryl nicotinate on serum Lp(a) and lipoprotein metabolism are discussed.
研究了低剂量（600毫克/天）的α-生育酚烟酸酯对28例高脂血症患者血清脂蛋白(a) [Lp(a)]浓度的影响。除Lp(a)外，治疗后血清脂质、脂蛋白和载脂蛋白均有升高趋势。特别是，高密度脂蛋白胆固醇和载脂蛋白C-II水平的变化具有统计学意义。另一方面，所有患者治疗2个月后血清Lp(a)水平显著下降。此外，初始Lp(a)水平低于18毫克/分升的组治疗前后无差异，而Lp(a)水平大于或等于18毫克/分升的组治疗后Lp(a)浓度显著下降。普罗布考和α-生育酚烟酸酯对血清Lp(a)、总胆固醇和高密度脂蛋白胆固醇的影响完全不同。讨论了α-生育酚烟酸酯对血清Lp(a)和脂蛋白代谢的可能机制。
