Hidiroglou N, Wolynetz M S, McDowell L R, Papas A M, Antapli M, Wilkinson N S
University of Florida, Department of Animal Science, Gainesville 32611.
Reprod Nutr Dev. 1993;33(3):263-8. doi: 10.1051/rnd:19930308.
A 61-d study involving 40 crossbred lambs evaluated the effect of various forms of tocopherol provided daily in equimolar amounts on total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in the serum of lambs. Thirty-five lambs were allotted to 7 treatment groups of 5 animals each, supplemented with 300 mg tocopherol either as: 1) DL-alpha-tocopheryl acetate; 2) D-alpha-tocopheryl acetate; 3) D-alpha-tocopheryl succinate; 4) D-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS); 5) DL-alpha-tocopheryl nicotinate; 6) DL-alpha-tocopheryl nicotinate (150 mg) + 150 mg TPGS; and 7-D-alpha-tocopheryl acetate (150 mg) + 150 mg TPGS mixed with the commercial flock diet. In addition, another group of 5 lambs were used as control (no vitamin E supplementation). Dietary supplementation of various vitamin E sources resulted in no overall treatment effects for total cholesterol, triglycerides or high density lipoprotein-cholesterol. A significant variation was noticed among animals. The levels of all measured serum components varied throughout the experimental period (P < 0.0001). The day x treatment interaction was not significant (P > 0.05) for any serum measured component. The present data strongly suggest that short-term treatment (< 2 mo) with pharmacological oral doses of various forms of vitamin E did not influence serum lipid metabolism of lambs. The data also showed that the bioavailability of alpha-tocopherol is dependent on the form administered. D-alpha-tocopherol acetate is a highly available form, the bioavailability of which is further increased when combined with D-alpha-tocopheryl polyethylene glycol succinate.
一项为期61天的研究涉及40只杂交羔羊，评估了每天以等摩尔量提供的各种形式生育酚对羔羊血清中总胆固醇、高密度脂蛋白胆固醇和甘油三酯浓度的影响。35只羔羊被分配到7个处理组，每组5只动物，每组补充300毫克生育酚，形式如下：1）DL-α-生育酚醋酸酯；2）D-α-生育酚醋酸酯；3）D-α-生育酚琥珀酸酯；4）D-α-生育酚聚乙二醇1000琥珀酸酯（TPGS）；5）DL-α-生育酚烟酸酯；6）DL-α-生育酚烟酸酯（150毫克）+150毫克TPGS；7）D-α-生育酚醋酸酯（150毫克）+150毫克TPGS与商业羊群饲料混合。此外，另一组5只羔羊用作对照（不补充维生素E）。日粮中添加各种维生素E来源对总胆固醇、甘油三酯或高密度脂蛋白胆固醇没有总体处理效果。在动物之间观察到显著差异。所有测量的血清成分水平在整个实验期间都有所变化（P<0.0001）。对于任何测量的血清成分，日×处理交互作用均不显著（P>0.05）。目前的数据强烈表明，用各种形式的维生素E进行药理学口服短期治疗（<2个月）不会影响羔羊的血清脂质代谢。数据还表明，α-生育酚的生物利用度取决于给药形式。D-α-生育酚醋酸酯是一种高度可用的形式，与D-α-生育酚聚乙二醇琥珀酸酯联合使用时，其生物利用度会进一步提高。
