Boyer H, de Gennes J L, Truffert J, Chatellier G, Dairou F, Bruckert E
Service d'Endocrinologie, Hôpital de la Pitié-Salpêtrière, Paris, France.
Atherosclerosis. 1990 Nov;85(1):61-9. doi: 10.1016/0021-9150(90)90183-j.
The serum lipoprotein Lp(a) concentration was measured in 1065 individuals in order to assess whether there was a relation between the type of dyslipidemia and the level of Lp(a). Males and females, aged between 2 and 83 years old, were included in the study. Quantification was performed by an immunonephelometric technique. The whole population was divided into normolipidemic (NL), type IIa without xanthoma (type IIa), type IIa with xanthoma (FH), type IIb and type IV phenotypes. Lp(a) level was arbitrarily divided into 5 subclasses in each group of dyslipidemia and in the normolipidemic group. In addition each group was divided according to sex and whether or not they were under treatment. We observed a significant difference between the median Lp(a) level of the normolipidemic group (NL) and of the dyslipidemic group as a whole. Median Lp(a) levels in the 4 dyslipidemic groups did not differ significantly. Sex, age and treatment did not influence the distribution of Lp(a) values distribution. Only weak correlations (Spearman's rank test) were observed between Lp(a) and other lipid parameters (total cholesterol, LDL, apo B, HDL, triglycerides): the highest correlation (r' = 0.15) was between Lp(a) and apo B. We conclude that Lp(a) level is not influenced by the type of dyslipidemia, sex or hypolipidemic drugs.
为了评估血脂异常类型与脂蛋白(a)[Lp(a)]水平之间是否存在关联，对1065名个体的血清Lp(a)浓度进行了测定。研究纳入了年龄在2岁至83岁之间的男性和女性。采用免疫比浊技术进行定量分析。将全部人群分为血脂正常（NL）、无黄色瘤的IIa型（IIa型）、有黄色瘤的IIa型（家族性高胆固醇血症，FH）、IIb型和IV型表型。在每个血脂异常组和血脂正常组中，Lp(a)水平被任意分为5个亚组。此外，每组还根据性别以及是否接受治疗进行了划分。我们观察到血脂正常组（NL）与整个血脂异常组的Lp(a)水平中位数之间存在显著差异。4个血脂异常组的Lp(a)水平中位数无显著差异。性别、年龄和治疗对Lp(a)值的分布没有影响。在Lp(a)与其他血脂参数（总胆固醇、低密度脂蛋白、载脂蛋白B、高密度脂蛋白、甘油三酯）之间仅观察到弱相关性（Spearman秩检验）：Lp(a)与载脂蛋白B之间的相关性最高（r' = 0.15）。我们得出结论，Lp(a)水平不受血脂异常类型、性别或降血脂药物的影响。
