Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal.
J Pediatr. 2011 Sep;159(3):447-53. doi: 10.1016/j.jpeds.2011.02.034. Epub 2011 Apr 14.
To assess the psychomotor development of the progeny of women from a moderately iodine-deficient area for whom thyroid function during pregnancy was measured.
The development of 86 children was assessed by the Bayley Scale of Infant Development at 12, 18, and 24 months.
Maternal serum free thyroxine (FT(4)) levels in the first trimester of pregnancy were the major determinant of psychomotor development at 18 and 24 months. Children born from mothers with FT(4) levels <25th percentile (<10 pg/mL) had an OR of 2.1 for mild-to-severe delay. Furthermore, alterations in behavior were already observed at 12 months and were related to subsequent changes in development. Neonatal thyroid status did not influence development.
This study highlights the need to implement active measures of iodine supplementation periconceptionally and during pregnancy and lactation because the negative effects on development and behavior might be prevented through preemptive action.
评估甲状腺功能在妊娠期间得到测量的来自碘中度缺乏地区的女性的后代的精神运动发育情况。
86 名儿童的发育情况通过贝利婴幼儿发展量表在 12、18 和 24 个月时进行评估。
妊娠早期的母亲血清游离甲状腺素（FT(4)）水平是 18 和 24 个月时精神运动发育的主要决定因素。FT(4)水平<第 25 百分位数（<10 pg/mL）的母亲所生的儿童发生轻度至重度发育迟缓的比值比（OR）为 2.1。此外，在 12 个月时已经观察到行为改变，并且与随后的发育变化有关。新生儿甲状腺功能状态并不影响发育。
本研究强调需要在妊娠前和妊娠期间及哺乳期实施积极的碘补充措施，因为通过预防措施可能防止对发育和行为的负面影响。
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