Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO, USA.
Ann Emerg Med. 2011 Sep;58(3):280-1. doi: 10.1016/j.annemergmed.2011.02.023. Epub 2011 Apr 14.
Severe salicylate poisoning is classically associated with an anion gap metabolic acidosis. However, high serum salicylate levels can cause false increase of laboratory chloride results on some analyzers. We present 2 cases of life-threatening salicylate poisoning with an apparently normal anion gap caused by an important laboratory interference. These cases highlight that the diagnosis of severe salicylism must be considered in all patients presenting with metabolic acidosis, even in the absence of an increased anion gap.
严重的水杨酸盐中毒通常与阴离子间隙型代谢性酸中毒有关。然而，高血清水杨酸盐水平可导致某些分析仪上实验室氯结果的假性升高。我们报告了 2 例因重要的实验室干扰而导致阴离子间隙似乎正常的危及生命的水杨酸盐中毒病例。这些病例强调，即使阴离子间隙没有增加，所有出现代谢性酸中毒的患者都必须考虑严重的水杨酸中毒的诊断。
