Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Otolaryngol Head Neck Surg. 2011 Feb;144(2):280-3. doi: 10.1177/0194599810391204.
To evaluate the maturity of the peripheral vestibular system in Down syndrome by examining the number of Scarpa's ganglion cells and the density of vestibular hair cells.
Case-control study using human temporal bones.
Tertiary academic center, otopathology laboratory.
Sixteen temporal bones from 8 patients with Down syndrome and 15 control temporal bones from 8 individuals with no history of otologic disease were selected. Hypoplasia of the lateral semicircular canal (LSC) and vestibule was investigated by measuring the dimensions of the structures. Scarpa's ganglion cells were counted under light microscopy. The vestibular hair cells were counted in the LSC crista and the utricular and saccular maculae under differential interference contrast (Nomarski) microscopy and expressed as density.
The patients with Down syndrome were divided into 2 groups: with and without LSC hypoplasia. The number of Scarpa's ganglion cells and the density of vestibular hair cells were significantly smaller in both groups of patients with Down syndrome than in the control group. There was no significant difference in the number of Scarpa's ganglion cells or the density of vestibular hair cells between the groups with and without LSC hypoplasia.
The peripheral vestibular system, including Scarpa's ganglion cells and vestibular hair cells, is hypoplastic irrespective of the vestibular malformation in Down syndrome.
通过检查 Scarpa 神经节细胞的数量和前庭毛细胞的密度，评估唐氏综合征患者外周前庭系统的成熟度。
采用人类颞骨的病例对照研究。
三级学术中心，耳病理学实验室。
选择 8 例唐氏综合征患者的 16 个颞骨和 8 例无耳病史的对照颞骨的 15 个颞骨。通过测量结构的尺寸来研究外侧半规管（LSC）和前庭的发育不良。在光镜下计数 Scarpa 神经节细胞。在相差干涉对比（诺玛斯基）显微镜下，对 LSC 嵴、椭圆囊和球囊斑中的前庭毛细胞进行计数，并表示为密度。
唐氏综合征患者分为两组：有和无 LSC 发育不良。两组唐氏综合征患者的 Scarpa 神经节细胞数量和前庭毛细胞密度均明显小于对照组。LSC 发育不良组和无 LSC 发育不良组之间的 Scarpa 神经节细胞数量或前庭毛细胞密度无显著差异。
唐氏综合征患者的外周前庭系统，包括 Scarpa 神经节细胞和前庭毛细胞，均存在发育不良，与前庭畸形无关。
