Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France.
Dermatology. 2011;222(3):217-20. doi: 10.1159/000326912. Epub 2011 Apr 13.
Cytophagic histiocytic panniculitis (CHP) is a rare disease mostly caused by viral infections and/or lymphoproliferative diseases. We describe a case of CHP associated with H1N1 vaccine during the winter 2009-2010 vaccination campaign and discuss the cutaneous side effects of influenza vaccines. A 6-year-old child presented with inflammatory subcutaneous nodules, which had appeared 1 month after the first injection of H1N1 vaccine and 1 week after the second injection. There was no history of recent infection. The skin lesions spontaneously disappeared without scarring. In CHP the abnormal cytokine secretion from neoplastic or reactive T cells promotes monocyte-macrophage activation and haemophagocytosis. Vaccination is not a common cause of CHP, but it seems possible that, as in infectious diseases, reactive T cells to the vaccine antigen could trigger CHP.
噬血细胞性组织细胞增生症（CHP）是一种罕见疾病，主要由病毒感染和/或淋巴组织增生性疾病引起。我们描述了一例与 2009-2010 年冬季 H1N1 疫苗接种相关的 CHP，并讨论了流感疫苗的皮肤副作用。一名 6 岁儿童出现炎症性皮下结节，首次接种 H1N1 疫苗后 1 个月，第二次接种后 1 周出现。近期无感染史。皮损自行消退，无瘢痕。在 CHP 中，异常细胞因子从肿瘤或反应性 T 细胞分泌，促进单核细胞-巨噬细胞活化和噬血细胞作用。疫苗接种不是 CHP 的常见原因，但似乎可能与传染病一样，疫苗抗原的反应性 T 细胞可能引发 CHP。
