Müller-Deile Janina, Schiffer Mario
Division of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
J Pregnancy. 2011;2011:176973. doi: 10.1155/2011/176973. Epub 2010 Dec 23.
Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy.
肾小球血管内皮生长因子（VEGF）的表达对于完整滤过屏障的维持和功能至关重要。肾小球VEGF生物利用度的改变会导致内皮细胞以及足细胞损伤。子痫前期的肾脏受累包括蛋白尿、足细胞尿、血压升高、水肿、肾小球毛细血管内皮病变和血栓性微血管病。至少，肾脏的体征、症状和其他证据可以通过VEGF水平降低得到充分解释。本文的目的是总结我们对子痫前期肾脏受累的病理生理学理解，并指出与VEGF消融治疗肾脏副作用的相似之处。
