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果蝇 TIEG 是参与翅膀图案形成和细胞增殖的不同信号通路的调节剂。

Drosophila TIEG is a modulator of different signalling pathways involved in wing patterning and cell proliferation.

机构信息

Centro de Biología Molecular Severo Ochoa CSIC-UAM, Universidad Autónoma de Madrid, Cantoblanco, Madrid, Spain.

出版信息

PLoS One. 2011 Apr 8;6(4):e18418. doi: 10.1371/journal.pone.0018418.

DOI:10.1371/journal.pone.0018418
PMID:21494610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3072976/
Abstract

Acquisition of a final shape and size during organ development requires a regulated program of growth and patterning controlled by a complex genetic network of signalling molecules that must be coordinated to provide positional information to each cell within the corresponding organ or tissue. The mechanism by which all these signals are coordinated to yield a final response is not well understood. Here, I have characterized the Drosophila ortholog of the human TGF-β Inducible Early Gene 1 (dTIEG). TIEG are zinc-finger proteins that belong to the Krüppel-like factor (KLF) family and were initially identified in human osteoblasts and pancreatic tumor cells for the ability to enhance TGF-β response. Using the developing wing of Drosophila as "in vivo" model, the dTIEG function has been studied in the control of cell proliferation and patterning. These results show that dTIEG can modulate Dpp signalling. Furthermore, dTIEG also regulates the activity of JAK/STAT pathway suggesting a conserved role of TIEG proteins as positive regulators of TGF-β signalling and as mediators of the crosstalk between signalling pathways acting in a same cellular context.

摘要

在器官发育过程中获得最终的形状和大小需要一个受调控的生长和模式形成程序，该程序由一个复杂的信号分子遗传网络控制，这些信号分子必须协调，以便为相应器官或组织内的每个细胞提供位置信息。目前还不清楚所有这些信号是如何协调产生最终反应的。在这里，我对人类 TGF-β诱导早期基因 1（dTIEG）的果蝇同源物进行了描述。TIEG 是锌指蛋白，属于 Krüppel 样因子（KLF）家族，最初在人类成骨细胞和胰腺肿瘤细胞中因其增强 TGF-β反应的能力而被鉴定。利用果蝇发育中的翅膀作为“体内”模型，研究了 dTIEG 在控制细胞增殖和模式形成中的作用。这些结果表明 dTIEG 可以调节 Dpp 信号。此外，dTIEG 还调节 JAK/STAT 途径的活性，这表明 TIEG 蛋白作为 TGF-β 信号的正调节剂和在同一细胞环境中发挥作用的信号通路之间的串扰的介质具有保守作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2187/3072976/5cdec064af4d/pone.0018418.g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2187/3072976/12b1da1b04e0/pone.0018418.g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2187/3072976/5cdec064af4d/pone.0018418.g008.jpg

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