Department of Gynaecology, St Marys Hospital, Manchester, United Kingdom.
Photochem Photobiol Sci. 2011 May;10(5):802-9. doi: 10.1039/c0pp00344a. Epub 2011 Apr 14.
Vulval intraepithelial neoplasia (VIN) is a premalignant condition of the vulva and its incidence is increasing. The common type of VIN is associated with oncogenic types of human papilloma virus (HPV) infection. The standard modalities of treatment for VIN, surgical excision and laser ablation, are both sub-optimal, associated with high rates of disease recurrence. There is a need for non-surgical treatment options for VIN and photodynamic therapy (PDT), by altering the local immunological parameters, has the potential to clear both VIN and HPV. This article reviews the studies of PDT treatment for VIN and discusses the clinical and immunological responses to PDT treatment in the various studies.
外阴上皮内瘤变（VIN）是外阴的一种癌前病变，其发病率正在增加。常见的 VIN 与致癌型人乳头瘤病毒（HPV）感染有关。VIN 的标准治疗方法是手术切除和激光消融，但这两种方法都不理想，疾病复发率都很高。因此，VIN 需要非手术治疗方法，而光动力疗法（PDT）通过改变局部免疫参数，有可能清除 VIN 和 HPV。本文综述了 PDT 治疗 VIN 的研究，并讨论了不同研究中 PDT 治疗的临床和免疫反应。
