Agakishiev D D, Makhmudov F R, Medzhidov N M
Vestn Dermatol Venerol. 1990(9):24-6.
This condition was described by Haxthausen in 1934 for the first time; it is one of the diseases explained by hyperkeratosis of the palms and soles. This disease is difficult to diagnose, and patients often complain of such conditions; therefore the authors consider it useful to regularly publish descriptions of clinical cases. Besides involvement of the palms and soles, manifesting by hyperkeratotic layers, painful fissures and itching, the patients with climacteric keratoderma develop metabolic endocrine, neurovegetative, and psychoemotional disorders. When choosing the treatment strategy, the physician should bear in mind specific features of the pathogenesis and clinical picture. Earlier therapy and its efficacy are of importance, as are the presence of allergies or drug intolerance and particulars of the climacteric period course in the first- and second-degree relatives.
这种病症于1934年由哈克斯豪森首次描述；它是由手掌和脚底角化过度所解释的疾病之一。这种疾病难以诊断，患者常为此类病症抱怨；因此，作者认为定期发表临床病例描述很有用。除了手掌和脚底受累，表现为角化过度层、疼痛性裂隙和瘙痒外，更年期角化病患者还会出现代谢内分泌、神经植物神经和心理情绪障碍。在选择治疗策略时，医生应牢记发病机制和临床表现的具体特征。早期治疗及其疗效很重要，一级和二级亲属中是否存在过敏或药物不耐受以及更年期病程细节也很重要。
