Deschamps P, Leroy D, Pedailles S, Mandard J C
Dermatologica. 1986;172(5):258-62. doi: 10.1159/000249351.
10 cases of keratoderma climactericum are reported. This keratosis of the palms and soles appears late in women of menopausal age. The keratotic lesions first develop at the plantar pressure points, making walking troublesome. Involvement of the hands remains discrete. Examination for contact allergy, fungal tests, vitamin A serum levels, and sex hormones were negative or normal in all the 10 patients. Microscopy revealed a lichenified eczema with evidence of mechanical irritation. Etretinate (0.78 mg/kg/day) brought about partial or total remission of the hyperkeratosis. Pain on walking disappeared in all the patients.
报告了10例更年期角化病。这种掌跖角化病出现在绝经年龄的女性中较晚。角化性病变首先出现在足底压力点，导致行走困难。手部受累仍较局限。所有10例患者的接触性过敏检查、真菌检测、血清维生素A水平和性激素检测均为阴性或正常。显微镜检查显示为苔藓化湿疹，有机械性刺激的证据。依曲替酯（0.78毫克/千克/天）使角化过度部分或完全缓解。所有患者行走时的疼痛均消失。
