Vasil'eva G G, Tsinzerling A V, Kozhemiakin L A, Bondarenko I G
Arkh Patol. 1990;52(7):20-6.
6 cases of HIV infection were revealed by enzyme immunoassay and immunoblotting among 144 children who had died in Elista. Another 5 children might have had HIV-infection but laboratory analyses either were lacking or gave doubtful results. Laboratory results were negative in 133 children. Similar severe changes of the lymphoid system typical for immunodeficiency were found in all children. These changes in HIV infection were characterized by lymphogenic generalized RNA infection. Complications (secondary diseases) in the form of DNA-virus infections (cytomegalia and herpes simplex), pneumocystosis and other viral and bacterial processes were observed in children of all groups. The disease was found mainly in Kalmyks. Blood examination of healthy Kalmyks revealed some differences in the form of significant decrease of the lysosomal cationic proteins content and the peroxydase activity of neutrophil leucocytes as compared to the same indexes obtained in Leningrad. There was also a tendency to the decrease of T-lymphocyte content. The children dying from immunodeficiencies lived mainly along the litoral of an ancient sea.
在埃利斯塔死亡的144名儿童中,通过酶免疫测定法和免疫印迹法发现6例感染了艾滋病毒。另外5名儿童可能感染了艾滋病毒,但缺乏实验室分析或结果存疑。133名儿童的实验室检查结果为阴性。在所有儿童中均发现了免疫缺陷典型的淋巴系统类似严重变化。这些艾滋病毒感染的变化特征为淋巴源性全身性RNA感染。在所有组的儿童中均观察到以DNA病毒感染(巨细胞病毒和单纯疱疹病毒)、肺孢子菌病以及其他病毒和细菌感染为形式的并发症(继发性疾病)。该疾病主要在卡尔梅克人当中发现。与列宁格勒的健康卡尔梅克人的相同指标相比,对健康卡尔梅克人的血液检查显示,溶酶体阳离子蛋白含量和中性粒细胞过氧化物酶活性显著降低。T淋巴细胞含量也有下降趋势。死于免疫缺陷的儿童主要居住在古代海洋的沿岸地区。