Ting Amal, Goss Jennifer M, McDougal Nolan T, Schaus Scott E
Department of Chemistry, Center for Chemical Methodology and Library Development Boston University, 24 Cummington Street, Boston, MA 02215, USA.
Top Curr Chem. 2010;291:145-200. doi: 10.1007/978-3-642-02815-1_23.
Chiral organic Brønsted bases have emerged as highly efficient catalysts for enantioselective transformations. Since their early use in enantiomeric separation processes, chiral organic Brønsted base catalysis has advanced significantly to include both natural and designed catalysts. Insight into the mode of action of the organocatalysts has promoted modifications in catalyst structures to expand the application to numerous asymmetric reactions. Bifunctional catalysts, containing both Brønsted base and H-activating functionalities, have proven to be very applicable to an array of reaction types. The development of Brønsted base catalysts containing or not containing H-activating moieties, has greatly impacted asymmetric organocatalysis. This overview illustrates the recent developments in this emerging field.
手性有机布朗斯特碱已成为对映选择性转化的高效催化剂。自从它们早期用于对映体分离过程以来，手性有机布朗斯特碱催化已取得显著进展，涵盖了天然催化剂和设计催化剂。对有机催化剂作用模式的深入了解推动了催化剂结构的改进，从而将其应用扩展到众多不对称反应中。含有布朗斯特碱和氢活化官能团的双功能催化剂已被证明非常适用于一系列反应类型。含或不含氢活化部分的布朗斯特碱催化剂的发展，对不对称有机催化产生了重大影响。本综述阐述了这一新兴领域的最新进展。
