Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555-0541, USA.
Cancer. 2011 Nov 1;117(21):5003-12. doi: 10.1002/cncr.26115. Epub 2011 Apr 14.
The authors' goal was to characterize hospice enrollment and aggressiveness of care for pancreatic cancer patients at the end of life.
Surveillance, Epidemiology, and End Results and linked Medicare claims data (1992-2006) were used to identify patients with pancreatic cancer who had died (n = 22,818). The authors evaluated hospice use, hospice enrollment ≥ 4 weeks before death, and aggressiveness of care as measured by receipt of chemotherapy, acute care hospitalization, and intensive care unit (ICU) admission in the last month of life.
Overall, 56.9% of patients enrolled in hospice, and 35.9% of hospice users enrolled for 4 weeks or more. Hospice use increased from 36.2% in 1992-1994 to 67.2% in 2004-2006 (P < .0001). Admission to the ICU and receipt of chemotherapy in the last month of life increased from 15.5% to 19.6% (P < .0001) and from 8.1% to 16.4% (P < .0001), respectively. Among patients with locoregional disease, those who underwent resection were less likely to enroll in hospice before death and much less likely to enroll early. They were also more likely to receive chemotherapy (14% vs 9%, P < .0001), be admitted to an acute care hospital (61% vs 53%, P < .0001), and be admitted to an ICU (27% vs 15%, P < .0001) in the last month of life.
Although hospice use increased over time, there was a simultaneous decrease in early enrollment and increase in aggressive care at the end of life for patients with pancreatic cancer.
作者的目标是描述胰腺癌患者在生命末期的临终关怀入院情况和治疗的积极程度。
使用监测、流行病学和最终结果(SEER)和相关的医疗保险索赔数据(1992-2006 年)来确定已死亡的胰腺癌患者(n=22818)。作者评估了临终关怀的使用、在死亡前 4 周或更早时间登记进入临终关怀以及在生命的最后一个月接受化疗、急性住院治疗和重症监护病房(ICU)入住等治疗的积极程度。
总体而言,56.9%的患者登记进入临终关怀,35.9%的临终关怀使用者登记进入临终关怀的时间超过 4 周。1992-1994 年至 2004-2006 年,临终关怀的使用比例从 36.2%增加到 67.2%(P<0.0001)。在生命的最后一个月入住 ICU 和接受化疗的比例从 15.5%增加到 19.6%(P<0.0001)和从 8.1%增加到 16.4%(P<0.0001)。在局部区域疾病患者中,接受手术的患者在死亡前登记进入临终关怀的可能性较小,早期登记的可能性更小。他们也更有可能接受化疗(14%比 9%,P<0.0001)、入住急性护理医院(61%比 53%,P<0.0001)和入住 ICU(27%比 15%,P<0.0001)。
尽管临终关怀的使用随着时间的推移而增加,但在胰腺癌患者生命的最后阶段,早期登记和积极治疗的比例同时下降。