Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy.
Curr Drug Metab. 2011 Sep;12(7):652-7. doi: 10.2174/138920011796504482.
Adverse drug reactions (ADRs) are a public health problem in older subjects, being responsible for a significant morbidity, disability and mortality. Older subjects are more susceptible to develop ADRs mainly due to polypharmacy, multimorbidity and inappropriate prescribing. The prevention of these drug related negative events represents an important aim for physicians treating older patients. Several strategies could potentially be employed, including state of the art education of medical students and physicians concerning principles of geriatric medicine and appropriate prescription in older subjects, reduction of inappropriate drug use by means of computerized decision support systems, pharmacist involvement and comprehensive geriatric assessment, and finally the identification of at risk older patients. However, there is currently a lack of scientific evidence demonstrating that these strategies can achieve a reduction in ADRs and therefore future intervention studies should be performed to evaluate the best intervention to decrease the burden of drug related problems in the older population.
药物不良反应（ADRs）是老年人群体中的一个公共卫生问题，可导致较高的发病率、失能率和死亡率。老年人更容易发生 ADR，主要是由于其多病共存和不合理用药。预防这些药物相关的不良事件是治疗老年患者的医生的一个重要目标。可以采用多种策略，包括为医学生和医生提供有关老年医学原则和老年人群体中合理处方的最新教育、利用计算机化决策支持系统减少不合理用药、药剂师的参与和全面的老年评估，以及最终确定有风险的老年患者。然而，目前缺乏科学证据表明这些策略可以减少 ADR，因此应开展未来的干预研究，以评估最佳干预措施，从而降低老年人群体中药物相关问题的负担。
