The Paul Mellon Laboratory of Equine Reproduction, Cheveley Park, Newmarket, UK.
Equine Vet J. 2011 Jul;43(4):430-8. doi: 10.1111/j.2042-3306.2010.00309.x. Epub 2011 Jan 19.
An opportunity to monitor equine chorionic gonadotrophin (eCG) production during 61 pregnancies in 25 Thoroughbred mares mated to the same Thoroughbred stallion was utilised in order to further knowledge regarding factors involved in the production of this hormone.
To examine the effects of maternal body condition, exercise and parity on eCG production.
In the first experiment, maiden mares were fed either a moderate (n = 9) or an excessive (n = 10) food intake throughout gestation. In the second experiment, 5 mares were exercised daily during pregnancy and eCG production rates were compared to 5 nonexercised mares. In the third experiment, eCG profiles were compared in 9 mares during 3 successive pregnancies. Equine chorionic gonadotrophin secretion was assessed as area under the curve (AUC), peak serum concentration, timing of the peak and the rate of decline. In addition, a mean eCG profile of 61 pregnancies was created to provide means and ranges for the above parameters.
In Experiment 1, eCG production was significantly higher in moderately rather than excessively fed mares in terms of AUC and peak eCG concentrations. In Experiment 2, the mean AUC did not differ between exercised and nonexercised animals but mean eCG concentrations were significantly higher in nonexercised mares between Days 60 and 90 of gestation. In Experiment 3, eCG became undetectable significantly earlier in gestation in the third parity. The mean eCG profile of 61 pregnancies showed a peak of 64.5 ± 3.7 iu/ml at 62.4 ± 1.0 days after ovulation and was undetectable by 134.1 ± 1.7 days. Peak eCG levels reduced by 50% 22.6 ± 1.13 days.
Some of the factors examined clearly influenced eCG production rate, the secretion of this hormone and its rate of disappearance from the blood.
The results provide insights into some factors that govern the production of the placental gonadotrophin, eCG.
本研究旨在监测 25 匹与同一匹纯血种公马配种的母马的 61 次妊娠期间的马绒毛膜促性腺激素（eCG）的产生情况，进一步了解影响这种激素产生的因素。
检查母体身体状况、运动和产次对 eCG 产生的影响。
在第一个实验中，9 匹初产母马在整个妊娠期内摄入适量（n=9）或过量（n=10）的食物。在第二个实验中，5 匹母马在妊娠期内每天运动，比较运动和不运动的母马的 eCG 产生率。在第三个实验中，比较了 9 匹母马在 3 次连续妊娠期间的 eCG 曲线。eCG 分泌评估为曲线下面积（AUC）、血清峰浓度、峰时间和下降率。此外，创建了 61 次妊娠的平均 eCG 曲线，提供了上述参数的平均值和范围。
在实验 1 中，适度喂养的母马的 eCG 产生量在 AUC 和峰值 eCG 浓度方面明显高于过度喂养的母马。在实验 2 中，运动和不运动动物之间的 AUC 平均值没有差异，但在妊娠 60-90 天之间，不运动的母马的平均 eCG 浓度明显更高。在实验 3 中，第三次产次的母马的 eCG 在妊娠早期明显更早地检测不到。61 次妊娠的平均 eCG 曲线显示，排卵后 62.4±1.0 天达到 64.5±3.7 iu/ml 的峰值，134.1±1.7 天检测不到。峰值 eCG 水平降低 50%需要 22.6±1.13 天。
一些检查的因素明显影响了 eCG 的产生速度、这种激素的分泌及其从血液中消失的速度。
研究结果提供了一些影响胎盘促性腺激素 eCG 产生的因素的见解。
