Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Equine Vet J. 2011 Nov;43(6):732-6. doi: 10.1111/j.2042-3306.2010.00337.x. Epub 2011 Mar 15.
Hoof health is a major concern of horse owners as well as the equine industry. However, many questions remain concerning regional variations of laminar junction and its potential to remodel.
To examine regional variations in the morphology of the laminar junction and thickness of the hoof wall in Thoroughbred horses.
The forefeet of 25 Thoroughbred cadavers were examined. Each hoof was divided into 20 blocks through 4 proximodistal slices (below the coronary band, each 1 cm apart) and 5 circumferential positions (toe, medial and lateral quarters and heels). In each block, 25 central primary epidermal laminae (PEL) were considered. Orientation of each lamina in relation to the hoof wall (LO), degree of bending (IA) and the spaces between the adjacent laminae (LS) were measured. Thickness of the hoof wall and number of branched PEL were also measured. Data were analysed using a split-block design in ANOVA.
There were significant differences between the 2 proximal and 2 distal slices in LO and IA data, but not in LS data. Circumferentially, toe blocks were different from heel and quarters blocks. Lateral and medial heels as well as the quarters were mostly different. The hoof wall was slightly thicker laterally than medially. There were more branched PEL on the lateral side of the left hooves and on the medial side of the right hooves.
These data add to the circumstantial evidence supporting the hypothesis of adaptive remodelling in the laminar junction. Results of this study signify the capability of PEL to remodel in response to applied stress to the regions of the hoof.
A deeper understanding of the gross and cellular processes of laminar remodelling may well prove to be complementary to an understanding of their failure in laminitis.
蹄健康是马主和马业关注的主要问题。然而，关于层状连接的区域变化及其潜在的重塑能力仍有许多问题尚未解决。
检查纯种马的层状连接形态和蹄壁厚度的区域变化。
检查了 25 匹纯种马的尸体前足。每个蹄子通过 4 个近-远切片（在冠状带下方，每个间隔 1 厘米）和 5 个周向位置（蹄、内侧和外侧 quarters 和脚跟）分为 20 个块。在每个块中，考虑了 25 个中央初级表皮层（PEL）。测量每个层相对于蹄壁的方向（LO）、弯曲程度（IA）和相邻层之间的空间（LS）。还测量了蹄壁的厚度和分支 PEL 的数量。使用方差分析的分裂块设计分析数据。
在 LO 和 IA 数据方面，近端和远端 2 个切片之间存在显著差异，但 LS 数据方面没有差异。在周向方面，蹄块与脚跟和 quarters 块不同。外侧和内侧脚跟以及 quarters 块大部分不同。蹄壁外侧比内侧稍厚。左侧蹄子的外侧和右侧蹄子的内侧有更多的分支 PEL。
这些数据增加了支持层状连接适应性重塑假说的间接证据。本研究的结果表明，PEL 有能力响应蹄子区域的应用应力进行重塑。
对层状重塑的宏观和细胞过程的更深入理解可能很好地补充了对其在蹄叶炎中失败的理解。
