镰状细胞贫血中的红细胞膜酶。2. 乙酰胆碱酯酶和ATP酶活性。
Erythrocyte membrane enzymes in sickle cell anemia. 2. Acetylcholinesterase and ATPase activities.
作者信息
Eluwa E O, Obidoa O, Ogan A U, Onwubiko H A
机构信息
Department of Biochemistry, University of Nigeria, Nsukka, Anambra State.
出版信息
Biochem Med Metab Biol. 1990 Dec;44(3):234-7. doi: 10.1016/0885-4505(90)90066-a.
The activity level of acetylcholinesterase in the erythrocytes of 32 patients homozygous for sickle cell anemia was determined and compared with that of normal AA controls as well as with that of AS individuals. Acetylcholinesterase activity was markedly higher in erythrocyte membrane from SS individuals than in those from AS individuals or AA controls. Additionally, ATPase activities were also significantly higher in sickle cell erythrocytes as compared to normal cells. These higher values of acetylcholinesterase and ATPase activities in SS erythrocytes may be explained as a consequence of the abnormally high cation levels in sickle cell erythrocytes.
测定了32例镰状细胞贫血纯合子患者红细胞中乙酰胆碱酯酶的活性水平，并与正常AA对照以及AS个体进行了比较。SS个体红细胞膜中的乙酰胆碱酯酶活性明显高于AS个体或AA对照。此外，与正常细胞相比，镰状细胞中的ATP酶活性也显著更高。SS红细胞中乙酰胆碱酯酶和ATP酶活性的这些较高值可能是镰状细胞中阳离子水平异常高的结果。
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