Postgraduate Endodontics Department, School of Dentistry, Pontificia Universidad Javeriana, Bogotá, Colombia.
J Endod. 2011 May;37(5):627-30. doi: 10.1016/j.joen.2011.02.013.
The purpose of this study was to quantify the effect of occlusal trauma experimentally induced with occlusal interferences on substance P (SP) expression in healthy human dental pulp and periodontal ligament.
Twenty-eight human dental pulp and periodontal ligament samples were obtained from healthy premolars in which extraction was indicated for orthodontic reasons. Before extraction, occlusal trauma was induced with experimental occlusal interferences in half of these premolars by placing a resin block over their occlusal surface and submitting patients to chew gum for 30 minutes. The remaining healthy premolars were extracted without occlusal trauma and served as a control group. All dental pulp and periodontal ligament samples were processed, and SP was measured by radioimmunoassay.
There was 45% and 120% greater SP expression in dental pulp and periodontal ligament, respectively, of teeth with experimentally induced occlusal trauma. Paired t test showed statistically significant differences for both human dental pulp and periodontal ligament (P = .02 and P < .001, respectively) of teeth submitted to occlusal trauma when compared with control group values.
SP expression in human dental pulp and periodontal ligament increases when teeth are submitted to occlusal trauma experimentally induced with occlusal interferences.
本研究旨在定量评估牙合干扰引起的牙合创伤对健康人牙髓和牙周组织中 P 物质（SP）表达的影响。
从因正畸需要拔除的健康前磨牙中获取 28 个人类牙髓和牙周组织样本。在这些前磨牙中，有一半在前磨牙的咬合面上放置树脂块，诱导实验性牙合干扰，让患者咀嚼口香糖 30 分钟，以诱导牙合创伤。剩余的健康前磨牙不进行牙合创伤处理作为对照组。所有牙髓和牙周组织样本均经过处理，通过放射免疫分析法测量 SP 的含量。
与对照组相比，实验性牙合创伤组的牙髓和牙周组织中 SP 的表达分别增加了 45%和 120%。配对 t 检验显示，两组的人牙髓和牙周组织均有统计学差异（P =.02 和 P <.001）。
当牙齿受到牙合干扰引起的牙合创伤时，人牙髓和牙周组织中 SP 的表达增加。
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