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Enhanced skin expression of melanoma differentiation-associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases.

作者信息

Zahn Sabine, Barchet Winfried, Rehkämper Claudia, Hornung Thorsten, Bieber Thomas, Tüting Thomas, Wenzel Jörg

出版信息

J Am Acad Dermatol. 2011 May;64(5):988-9. doi: 10.1016/j.jaad.2010.08.004.

DOI:10.1016/j.jaad.2010.08.004
PMID:21496705
Abstract
摘要

相似文献

1
Enhanced skin expression of melanoma differentiation-associated gene 5 (MDA5) in dermatomyositis and related autoimmune diseases.皮肌炎及相关自身免疫性疾病中黑色素瘤分化相关基因5（MDA5）在皮肤中的表达增强。
J Am Acad Dermatol. 2011 May;64(5):988-9. doi: 10.1016/j.jaad.2010.08.004.
2
Dermatomyositis With or Without Anti-Melanoma Differentiation-Associated Gene 5 Antibodies: Common Interferon Signature but Distinct NOS2 Expression.伴或不伴抗黑色素瘤分化相关基因5抗体的皮肌炎：共同的干扰素特征但不同的NOS2表达
Am J Pathol. 2016 Mar;186(3):691-700. doi: 10.1016/j.ajpath.2015.11.010. Epub 2016 Jan 21.
3
Autoimmune disorders associated with gain of function of the intracellular sensor MDA5.与细胞内传感器 MDA5 功能获得相关的自身免疫性疾病。
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4
Serum interferon-α is a useful biomarker in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis.血清干扰素-α是抗黑色素瘤分化相关基因5（MDA5）抗体阳性皮肌炎患者的一种有用生物标志物。
Mod Rheumatol. 2015 Jan;25(1):85-9. doi: 10.3109/14397595.2014.900843. Epub 2014 Apr 9.
5
Basiliximab may improve the survival rate of rapidly progressive interstitial pneumonia in patients with clinically amyopathic dermatomyositis with anti-MDA5 antibody.巴利昔单抗可能会提高抗MDA5抗体阳性的临床无肌病性皮肌炎患者快速进展性间质性肺炎的生存率。
Ann Rheum Dis. 2014 Aug;73(8):1591-3. doi: 10.1136/annrheumdis-2014-205278. Epub 2014 Apr 16.
6
Amyophatic dermatomyositis presenting as a flagellated skin eruption with positive MDA5 antibodies and thyroid cancer: a real association?
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7
Constitutive antiviral immunity at the expense of autoimmunity.以自身免疫为代价的固有抗病毒免疫。
Immunity. 2014 Feb 20;40(2):167-9. doi: 10.1016/j.immuni.2014.01.009.
8
Anti-MDA5 positive clinically amyopathic dermatomyositis presenting with severe cardiomyopathy.抗MDA5阳性的临床无肌病性皮肌炎伴严重心肌病。
J Eur Acad Dermatol Venereol. 2014 Aug;28(8):1097-1102. doi: 10.1111/jdv.12300.
9
Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: A concise review with an emphasis on distinctive clinical features.抗黑色素瘤分化相关基因 5（MDA5）皮肌炎：简明综述，重点介绍独特的临床特征。
J Am Acad Dermatol. 2018 Apr;78(4):776-785. doi: 10.1016/j.jaad.2017.12.010. Epub 2017 Dec 9.
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Detection of anti-CADM-140/MDA5 antibodies in a patient with classic dermatomyositis developing rapidly progressive interstitial lung disease.在一名患有典型皮肌炎并发展为快速进展性间质性肺病的患者中检测抗CADM-140/MDA5抗体。
J Dermatol. 2014 Jul;41(7):664-5. doi: 10.1111/1346-8138.12524. Epub 2014 Jun 14.

引用本文的文献

1
Anti- Melanoma Differentiation-Associated Gene 5 Antibody Positive Dermatomyositis: Recent Progress in Pathophysiology and Treatment.抗黑色素瘤分化相关基因5抗体阳性皮肌炎：病理生理学与治疗的最新进展
Curr Rheumatol Rep. 2025 May 5;27(1):23. doi: 10.1007/s11926-025-01188-7.
2
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.介导持续性内质网应激/未折叠蛋白反应的MDA5蛋白促成皮肌炎中肺微血管内皮细胞的内皮-间充质转化。
Cell Commun Signal. 2025 Mar 23;23(1):149. doi: 10.1186/s12964-025-02159-2.
3
Treatment of Calcinosis in Dermatomyositis-Case Report and Review.
皮肌炎中钙质沉着症的治疗——病例报告及综述
J Clin Med. 2024 Oct 18;13(20):6234. doi: 10.3390/jcm13206234.
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Heterozygous de novo dominant negative mutation of REXO2 results in interferonopathy.REXO2 杂合新生显性负性突变导致干扰素病。
Nat Commun. 2024 Aug 6;15(1):6685. doi: 10.1038/s41467-024-50878-w.
5
Genome-wide identification of dysregulated alternative splicing and RNA-binding proteins involved in atopic dermatitis.全基因组范围内对特应性皮炎中失调的可变剪接和RNA结合蛋白的鉴定。
Front Genet. 2024 Mar 1;15:1287111. doi: 10.3389/fgene.2024.1287111. eCollection 2024.
6
Bioinformatics analyses of gene expression profile to identify pathogenic mechanisms for COVID-19 infection and cutaneous lupus erythematosus.基于基因表达谱的生物信息学分析，以鉴定 COVID-19 感染和红斑狼疮的发病机制。
Front Immunol. 2023 Oct 31;14:1268912. doi: 10.3389/fimmu.2023.1268912. eCollection 2023.
7
The central helicase domain holds the major conformational epitopes of melanoma differentiation-associated gene 5 autoantibodies.中央解旋酶结构域包含黑色素瘤分化相关基因 5 自身抗体的主要构象表位。
Rheumatology (Oxford). 2024 May 2;63(5):1456-1465. doi: 10.1093/rheumatology/kead397.
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Predictors of progression in idiopathic inflammatory myopathies with interstitial lung disease.伴有间质性肺病的特发性炎性肌病进展的预测因素。
J Transl Int Med. 2022 Nov 15;11(1):46-56. doi: 10.2478/jtim-2022-0029. eCollection 2023 Mar.
9
Roles of biomarkers in anti-MDA5-positive dermatomyositis, associated interstitial lung disease, and rapidly progressive interstitial lung disease.生物标志物在抗 MDA5 阳性皮肌炎、相关间质性肺病和快速进展性间质性肺病中的作用。
J Clin Lab Anal. 2022 Nov;36(11):e24726. doi: 10.1002/jcla.24726. Epub 2022 Oct 12.
10
Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases.靶向天然免疫传感器在自身免疫性疾病治疗中的应用与前景
Cell Biosci. 2022 May 26;12(1):68. doi: 10.1186/s13578-022-00810-w.