van Eeden A, Schotborgh R H, Tytgat G N
Academic Medical Center, University of Amsterdam, The Netherlands.
Clin Ther. 1990 Nov-Dec;12(6):496-502.
The effects of two nonsteroidal anti-inflammatory drugs on the gastroduodenal mucosa were evaluated by endoscopy and direct photography in 36 healthy men who were randomly assigned to receive 150 mg of diclofenac, 1,200 mg of etodolac, or 600 mg of etodolac daily for seven days. Endoscopy was performed on days 1 and 8. Mild gastric lesions were observed in six subjects. The mean (+/- SD) endoscopy scores on a five-point scale were 0.08 +/- 0.27 after 600 mg of etodolac, 0.25 +/- 0.53 after 1,200 mg of etodolac, and 0.33 +/- 0.62 after diclofenac. No between-group differences were statistically significant. No duodenal lesions were seen. A strong correlation was found between endoscopy scores and photographic reviews. The results indicate that both etodolac and diclofenac cause minimal changes on the gastric mucosa.
通过内镜检查和直接摄影，对36名健康男性服用两种非甾体抗炎药后胃十二指肠黏膜的影响进行了评估。这些男性被随机分配，分别每日服用150毫克双氯芬酸、1200毫克依托度酸或600毫克依托度酸，为期7天。在第1天和第8天进行了内镜检查。在6名受试者中观察到轻度胃部病变。在五分制评分中，服用600毫克依托度酸后的内镜平均（±标准差）评分为0.08±0.27，服用1200毫克依托度酸后为0.25±0.53，服用双氯芬酸后为0.33±0.62。组间差异无统计学意义。未观察到十二指肠病变。内镜评分与摄影评估之间存在很强的相关性。结果表明，依托度酸和双氯芬酸对胃黏膜造成的变化均极小。
