Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas, USA.
J Urol. 2011 Jun;185(6):2137-42. doi: 10.1016/j.juro.2011.02.052. Epub 2011 Apr 15.
Periodic Health Assessments have been mandated for United States Air Force servicemen since the mid 1990s. Thus, we determined whether United States Air Force prostate cancer incidence rates increased thereafter and how these tumors segregate into low and intermediate/high risk categories. We also identified treatment choices.
We queried the Department of Defense Automated Central Tumor Registry for prostate cancer diagnosed in United States Air Force servicemen between 1991 and 2008 to determine incidence rates, disease risk category and treatments.
Age adjusted rates in white active duty servicemen diagnosed for the most recent period of 2005 to 2008 increased 3-fold relative to the rate in the earliest period of 1991 to 1994. A similar trend was evident in black servicemen. Relative to the Surveillance, Epidemiology and End Results population prostate cancer rates in active duty United States Air Force men between 1995 and 2008 were significantly increased for the 2 racial groups. A significantly greater proportion of active duty servicemen than retirees (62% vs 40%) presented with low risk disease, defined as prostate specific antigen less than 10 ng/ml, Gleason sum less than 7 and clinical stage T1a-T2a. Of those with low risk disease significantly more active duty servicemen elected curative surgery than retirees (93% vs 53%).
Prostate cancer incidence rates in United States Air Force servicemen have increased with time, exceeding rates in the Surveillance, Epidemiology and End Results population. While most cases are characterized as low risk, aggressive management is elected.
自 20 世纪 90 年代中期以来，美国空军的男性军人就被要求进行定期健康评估。因此，我们确定此后美国空军前列腺癌的发病率是否增加，以及这些肿瘤如何分为低危和中高危类别。我们还确定了治疗选择。
我们查询了国防部自动中央肿瘤登记处，以确定在 1991 年至 2008 年期间被诊断为前列腺癌的美国空军男性军人的发病率、疾病风险类别和治疗方法。
与 1991 年至 1994 年的最早时期相比，2005 年至 2008 年期间被诊断为最新时期的白种现役军人的年龄调整发病率增加了 3 倍。黑种军人也有类似的趋势。与监测、流行病学和结果人群相比，1995 年至 2008 年期间美国空军现役男性的前列腺癌发病率在这两个种族群体中均显著增加。与退休军人相比（62%比 40%），现役军人中患有低危疾病（定义为前列腺特异性抗原<10ng/ml、Gleason 总和<7 和临床分期 T1a-T2a）的比例显著更高。在患有低危疾病的现役军人中，选择根治性手术的比例明显高于退休军人（93%比 53%）。
美国空军男性军人的前列腺癌发病率随时间推移而增加，超过了监测、流行病学和结果人群的发病率。虽然大多数病例被认为是低危，但选择了积极的治疗方法。
