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创伤后应激障碍与焦虑和抑郁障碍结构关系的研究。

An examination of the structure of posttraumatic stress disorder in relation to the anxiety and depressive disorders.

机构信息

Australian Centre for Posttraumatic Mental Health and Department of Psychiatry, University of Melbourne, Victoria, Australia.

出版信息

J Affect Disord. 2011 Jul;132(1-2):165-72. doi: 10.1016/j.jad.2011.02.011. Epub 2011 Apr 14.

DOI:10.1016/j.jad.2011.02.011
PMID:21496930
Abstract

The nature and structure of posttraumatic stress disorder (PTSD) has been the subject of much interest in recent times. This research has been represented by two streams, the first representing a substantive body of work which focuses specifically on the factor structure of PTSD and the second exploring PTSD's relationship with other mood and anxiety disorders. The present study attempted to bring these two streams together by examining structural models of PTSD and their relationship with dimensions underlying other mood and anxiety disorders. PTSD, anxiety and mood disorder data from 989 injury survivors interviewed 3-months following their injury were analyzed using a series of confirmatory factor analyses (CFA) to identify the optimal structural model. CFA analyses indicated that the best fitting model included PTSD's re-experiencing (B1-5), active avoidance (C1-2), and hypervigilance and startle (D4-5) loading onto a Fear factor (represented by panic disorder, agoraphobia and social phobia) and the PTSD dysphoria symptoms (numbing symptoms C3-7 and hyperarousal symptoms D1-3) loading onto an Anxious Misery/Distress factor (represented by depression, generalized anxiety disorder and obsessive compulsive disorder). The findings have implications for informing potential revisions to the structure of the diagnosis of PTSD and the diagnostic algorithm to be applied, with the aim of enhancing diagnostic specificity.

摘要

创伤后应激障碍(PTSD)的性质和结构一直是近来许多研究关注的焦点。这方面的研究主要有两个流派,第一个流派代表了大量专门关注 PTSD 因素结构的工作,第二个流派则探索了 PTSD 与其他情绪和焦虑障碍的关系。本研究试图通过检查 PTSD 的结构模型及其与其他情绪和焦虑障碍潜在维度的关系,将这两个流派结合起来。对 989 名创伤后幸存者的 PTSD、焦虑和情绪障碍数据进行了分析,这些幸存者在受伤后 3 个月接受了访谈,采用一系列验证性因子分析(CFA)来确定最佳的结构模型。CFA 分析表明,最佳拟合模型包括 PTSD 的再体验(B1-5)、主动回避(C1-2)和过度警惕和惊跳反应(D4-5),这些症状加载到恐惧因子(由惊恐障碍、广场恐怖症和社交恐怖症代表),PTSD 苦恼症状(麻木症状 C3-7 和过度警觉症状 D1-3)加载到焦虑痛苦/困扰因子(由抑郁、广泛性焦虑障碍和强迫症代表)。这些发现对告知 PTSD 诊断结构的潜在修订和应用的诊断算法具有重要意义,目的是提高诊断的特异性。

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