Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Diabetes Res Clin Pract. 2011 Jul;93(1):86-94. doi: 10.1016/j.diabres.2011.03.016. Epub 2011 Apr 14.
The aim of the present study was to determine if micronutrients supplementation can improve neuropathy indices in type 2 diabetes.
In this randomized, double-blind, placebo-controlled clinical trial, 75 type 2 diabetes patients were assigned to three treatment groups, receiving one of the following daily supplement for 4 months: Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg); Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg), biotin (200 μg), B12 (10 μg) and folic acid (1 mg); Group P: placebo.
67 patients completed the study. Neuropathic symptoms based on the MNSI questionnaire improved from 3.45 to 0.64 (p=0.001) in group MVB, from 3.96 to 1.0 (p=0.001) in group MV and from 2.54 to 1.95 in placebo group after 4 months. There was no significant difference between three treatment groups in MNSI examinations after 4 months supplementations. Over 4 months of treatment, patients showed no significant changes in glycemic control, capillary blood flow or electrophysiological measures in MV and MVB groups compared with placebo group.
These studies suggest that micronutrients supplementation might ameliorate diabetic neuropathy symptoms.
本研究旨在确定补充微量营养素是否可以改善 2 型糖尿病患者的神经病变指数。
在这项随机、双盲、安慰剂对照的临床试验中，将 75 名 2 型糖尿病患者分为三组，分别接受以下每日补充剂治疗 4 个月：MV 组：锌（20 毫克）、镁（250 毫克）、维生素 C（200 毫克）和 E（100 毫克）；MVB 组：上述矿物质和维生素补充剂加维生素 B1（10 毫克）、B2（10 毫克）、B6（10 毫克）、生物素（200μg）、B12（10μg）和叶酸（1mg）；P 组：安慰剂。
67 名患者完成了研究。根据 MNSI 问卷，MVB 组的神经病变症状从 3.45 分改善至 0.64 分（p=0.001），MV 组从 3.96 分改善至 1.0 分（p=0.001），安慰剂组从 2.54 分改善至 1.95 分。4 个月补充后，三组间 MNSI 检查无显著差异。与安慰剂组相比，MV 和 MVB 组在 4 个月的治疗期间，血糖控制、毛细血管血流或电生理测量均无显著变化。
这些研究表明，补充微量营养素可能改善糖尿病神经病变症状。
