Department of Psychiatry, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, People's Republic of China.
Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
Mol Neurobiol. 2023 Aug;60(8):4574-4594. doi: 10.1007/s12035-023-03342-7. Epub 2023 Apr 28.
Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus with a high incidence. Oxidative stress, which is a crucial pathophysiological pathway of DPN, has attracted much attention. The distortion in the redox balance due to the overproduction of reactive oxygen species (ROS) and the deregulation of antioxidant defense systems promotes oxidative damage in DPN. Therefore, we have focused on the role of oxidative stress in the pathogenesis of DPN and elucidated its interaction with other physiological pathways, such as the glycolytic pathway, polyol pathway, advanced glycosylation end products, protein kinase C pathway, inflammation, and non-coding RNAs. These interactions provide novel therapeutic options targeting oxidative stress for DPN. Furthermore, our review addresses the latest therapeutic strategies targeting oxidative stress for the rehabilitation of DPN. Antioxidant supplements and exercise have been proposed as fundamental therapeutic strategies for diabetic patients through ROS-mediated mechanisms. In addition, several novel drug delivery systems can improve the bioavailability of antioxidants and the efficacy of DPN.
糖尿病周围神经病变（DPN）是糖尿病的一种主要并发症，发病率较高。氧化应激是 DPN 的一个关键病理生理途径，引起了广泛关注。由于活性氧（ROS）的过度产生和抗氧化防御系统的失调导致氧化还原平衡的扭曲，促进了 DPN 中的氧化损伤。因此，我们专注于氧化应激在 DPN 发病机制中的作用，并阐明了其与其他生理途径（如糖酵解途径、多元醇途径、晚期糖基化终产物、蛋白激酶 C 途径、炎症和非编码 RNA）的相互作用。这些相互作用为 DPN 的氧化应激提供了新的治疗选择。此外，我们的综述还探讨了针对氧化应激的最新治疗策略，以促进 DPN 的康复。抗氧化补充剂和运动已被提议作为通过 ROS 介导的机制治疗糖尿病患者的基本治疗策略。此外，几种新型药物输送系统可以提高抗氧化剂的生物利用度和 DPN 的疗效。
