Koshika Kyotaro, Ichinohe Tatsuya, Kaneko Yuzuru
Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
J Oral Maxillofac Surg. 2011 Aug;69(8):2128-34. doi: 10.1016/j.joms.2010.12.056. Epub 2011 Apr 15.
The aim of this study was to investigate the effect of remifentanil continuous infusion on the blood flow in rabbit oral tissue during propofol and sevoflurane anesthesia, as well as its dose dependency.
Sixteen male tracheotomized Japan white rabbits were anesthetized with propofol or sevoflurane under mechanical ventilation. The infusion rate of remifentanil was 0.1, 0.2, 0.4, 0.8, and 1.6 μg·kg(-1)·min(-1), respectively, for 20 minutes. Observed variables were systolic blood pressure (SBP), diastolic blood pressure, mean arterial pressure (MAP), heart rate (HR), common carotid artery blood flow, tongue mucosal blood flow (TBF), mandibular bone marrow blood flow (BBF), masseter muscle blood flow (MBF), upper alveolar tissue blood flow (UBF), and lower alveolar tissue blood flow (LBF).
HR, SBP, MAP, TBF, BBF, MBF, UBF, and LBF showed dose-dependent decreases during remifentanil infusion with both propofol and sevoflurane anesthesia. The decreases in BBF, MBF, UBF, and LBF explained as a percent change were greater than those in HR, SBP, MAP, and TBF. In the sevoflurane group, there were no changes in diastolic blood pressure and common carotid artery blood flow during remifentanil infusion.
Our findings suggest that infusion of remifentanil reduces TBF, BBF, MBF, UBF, and LBF in a dose-dependent manner without a significant reduction in MAP during propofol and sevoflurane anesthesia.
本研究旨在探讨瑞芬太尼持续输注对兔在丙泊酚和七氟醚麻醉期间口腔组织血流的影响及其剂量依赖性。
16只雄性经气管切开的日本白兔在机械通气下用丙泊酚或七氟醚麻醉。瑞芬太尼的输注速率分别为0.1、0.2、0.4、0.8和1.6μg·kg⁻¹·min⁻¹，持续20分钟。观察指标包括收缩压（SBP）、舒张压、平均动脉压（MAP）、心率（HR）、颈总动脉血流、舌黏膜血流（TBF）、下颌骨骨髓血流（BBF）、咬肌血流（MBF）、上牙槽组织血流（UBF）和下牙槽组织血流（LBF）。
在丙泊酚和七氟醚麻醉下瑞芬太尼输注期间，HR、SBP、MAP、TBF、BBF、MBF、UBF和LBF均呈剂量依赖性下降。以百分比变化表示，BBF、MBF、UBF和LBF的下降幅度大于HR、SBP、MAP和TBF。在七氟醚组中，瑞芬太尼输注期间舒张压和颈总动脉血流无变化。
我们的研究结果表明，在丙泊酚和七氟醚麻醉期间，输注瑞芬太尼可使TBF、BBF、MBF、UBF和LBF呈剂量依赖性降低，而MAP无显著降低。
