Division of Neonatology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, the Netherlands.
Early Hum Dev. 2011 Jun;87(6):401-6. doi: 10.1016/j.earlhumdev.2011.03.002. Epub 2011 Apr 14.
Our aim was to determine the influence of prenatal tobacco exposure on regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants. We hypothesized that as a result of vasoconstriction caused by prenatal tobacco exposure r(c)SO(2) would be lower and FTOE would be higher during the first days after birth in infants exposed to tobacco during pregnancy.
Sixty preterms were included in this prospective, observational cohort study (median gestational age 29.9 weeks, range 26.0-31.8, median birth weight 1248 g, range 615-2250). Fourteen infants had been exposed to tobacco during pregnancy. All mothers smoked more than five cigarettes a day till delivery. We measured r(c)SO(2) and transcutaneous arterial oxygen saturation (tcSaO(2)) in all infants on days 1-5, 8, and 15. FTOE was calculated: FTOE=(tcSaO(2)-r(c)SO(2))/tcSaO(2).
In preterm infants exposed to tobacco during pregnancy, r(c)SO(2) was lower during days 1, 2, and 8 after birth, median 73% versus 81%, 73% versus 80% and 71% versus 78% respectively. FTOE was higher during days 1 and 8 after birth, median 0.24 versus 0.15 and 0.26 versus 0.19 respectively. On the second day, FTOE tended to be higher, 0.18 versus 0.14.
During the first two days and day 8 after birth cerebral oxygen saturation is lower and oxygen extraction higher in preterm infants following prenatal tobacco exposure. Our data suggest that prenatal tobacco exposure may have an effect on cerebral oxygenation of the infant.
本研究旨在探讨产前烟草暴露对早产儿脑局部组织氧饱和度（r(c)SO(2)）和局部组织氧摄取分数（FTOE）的影响。我们假设，由于产前烟草暴露引起的血管收缩，在妊娠期间暴露于烟草的早产儿在出生后最初几天，r(c)SO(2) 会更低，FTOE 会更高。
本前瞻性观察性队列研究纳入了 60 例早产儿（中位胎龄 29.9 周，范围为 26.0-31.8，中位出生体重 1248g，范围为 615-2250g）。14 例婴儿在妊娠期间暴露于烟草。所有母亲在分娩前每天吸烟超过 5 支。我们在所有婴儿出生后第 1-5 天、第 8 天和第 15 天测量 r(c)SO(2)和经皮动脉氧饱和度（tcSaO(2)）。FTOE 计算方法为：FTOE=(tcSaO(2)-r(c)SO(2))/tcSaO(2)。
在妊娠期间暴露于烟草的早产儿中，r(c)SO(2)在出生后第 1、2 和 8 天较低，中位数分别为 73%比 81%、73%比 80%和 71%比 78%。FTOE 在出生后第 1 和第 8 天较高，中位数分别为 0.24 比 0.15 和 0.26 比 0.19。在第 2 天，FTOE 也有升高趋势，中位数为 0.18 比 0.14。
在出生后最初两天和第 8 天，产前烟草暴露的早产儿脑氧饱和度较低，氧摄取分数较高。我们的数据表明，产前烟草暴露可能对婴儿的脑氧合有影响。
