Department of Psychiatry, University of California-San Diego, San Diego, CA, USA.
Addict Behav. 2011 Aug;36(8):886-9. doi: 10.1016/j.addbeh.2011.03.012. Epub 2011 Mar 25.
The present study examined the effects of alcohol consumption on narrative recall and contextual memory among individuals with and without a history of fragmentary blackouts in an attempt to better understand why some individuals experience alcohol-induced memory impairments whereas others do not, even at comparable blood alcohol concentrations (BACs). Standardized beverage (alcohol and no alcohol) administration procedures and neuropsychological assessments measured narrative recall and context memory performance before and after alcohol consumption in individuals with (n=44) and without (n=44) a history of fragmentary blackouts. Findings indicate that acute alcohol intoxication led to impairments in free recall, but not next-day cued recall. Further, participants showed similar memory performance when sober, but individuals who consumed alcohol and had a positive history of fragmentary blackouts showed greater contextual memory impairments than those who had not previously experienced a fragmentary blackout. Thus, it appears that some individuals may have an inherent vulnerability to alcohol-induced memory impairments due to alcohol's effects on contextual memory processes.
本研究旨在探讨饮酒对有和无片段性醉酒史个体的叙事性回忆和情境记忆的影响，试图更好地理解为什么有些人即使在相当的血液酒精浓度 (BAC) 下也会出现酒精引起的记忆损伤，而有些人则不会。在有（n=44）和无（n=44）片段性醉酒史的个体中，通过标准化的饮料（酒精和非酒精）管理程序和神经心理学评估，在饮酒前后测量了叙事性回忆和情境记忆表现。研究结果表明，急性酒精中毒会导致自由回忆受损，但第二天的线索回忆不受影响。此外，清醒时参与者的记忆表现相似，但曾有过片段性醉酒史且饮酒的参与者的情境记忆损伤比以前没有经历过片段性醉酒史的参与者更大。因此，由于酒精对情境记忆过程的影响，一些人可能对酒精引起的记忆损伤具有内在的脆弱性。
