Department of Bioengineering, University of Washington, Seattle, WA, USA; Corazonx, Inc., Seattle, WA 98195, USA.
Ultrasound Med Biol. 2011 May;37(5):679-87. doi: 10.1016/j.ultrasmedbio.2011.02.008.
Coronary artery vibrometry is a new transthoracic Doppler ultrasound method for the detection of coronary artery stenosis. It detects audio-frequency vibrations generated by coronary artery luminal diameter reduction. We studied 31 patients with known or suspected stenosis using coronary artery vibrometry and quantitative coronary angiography and 83 normal volunteers. A tissue vibration difference index (TVDI) was calculated from the left anterior descending, circumflex, left main and right coronary arteries. Accuracy for coronary artery stenosis detection using TVDI was assessed. Sensitivity for detecting coronary stenosis equal or greater than 25% diameter reduction was 89% in the left anterior descending coronary artery (16/18, 95% confidence interval [CI] = 64%-98%), 87% in the right coronary artery (13/15, 95% CI = 58%-98%), 83% in the circumflex coronary artery (5/6, 95% CI = 36%-99%) and 100% in the left main artery (3/3, 95% CI = 31%-100%). The median TVDI increased with severity of stenosis, suggesting that this measure might be used to track progression/regression of coronary artery stenosis.
冠状动脉振动测量是一种新的经胸多普勒超声方法，用于检测冠状动脉狭窄。它检测到由冠状动脉管腔直径减小产生的音频振动。我们使用冠状动脉振动测量法和定量冠状动脉造影对 31 名已知或疑似狭窄的患者以及 83 名正常志愿者进行了研究。从左前降支、回旋支、左主干和右冠状动脉计算出组织振动差指数（TVDI）。评估了使用 TVDI 检测冠状动脉狭窄的准确性。TVDI 检测左前降支冠状动脉狭窄程度等于或大于 25%的敏感性为 89%（16/18，95%置信区间 [CI] = 64%-98%），右冠状动脉为 87%（13/15，95%CI = 58%-98%），回旋支为 83%（5/6，95%CI = 36%-99%），左主干为 100%（3/3，95%CI = 31%-100%）。TVDI 的中位数随着狭窄程度的增加而增加，这表明该测量方法可能用于跟踪冠状动脉狭窄的进展/消退。
