Lee Daehyeon, Yoo Sungjoo, Kim Dong-Bin
Department of Electrical Engineering, Pohang University of Science and Technology, Pohang, Korea.
Department of Computer Science and Engineering, Seoul National University, Seoul, Korea.
Echocardiography. 2019 Aug;36(8):1467-1474. doi: 10.1111/echo.14447. Epub 2019 Aug 12.
The turbulence of blood flow caused by stenosis has an impact on the surrounding coronary artery tissue and creates an audio-frequency vibration to the adjacent myocardial wall. We investigated the diagnostic feasibility of a novel diagnostic method using wide range gate (WRG) ultrasound data acquisition for diagnosing coronary artery disease (CAD). WRG data acquisition detects high-frequency vibrations from coronary artery stenosis, using pulse-wave Doppler ultrasound.
We used a Verasonics ultrasound data acquisition system to implement the WRG data acquisition. Investigators performed clinical trials for 80 subjects, with suspected CAD. All enrolled patients participated in WRG data acquisition before coronary angiography (CAG).
As compared with the results of CAG, the sensitivity and specificity of the WRG data analysis were 80% and 84%, respectively. The WRG data analysis showed that the sensitivity and specificity were 81% and 79% in the left anterior descending artery, respectively, 75% and 89% in the left circumflex artery, respectively, and 85% and 82% in the right coronary artery, respectively. In a multivariate analysis, a positive vibrometry result was an independent predictive factor for CAD.
We proposed a new diagnostic method for detecting CAD using ultrasound. The new data acquisition method showed good potential as an initial diagnostic tool for CAD.
狭窄引起的血流紊乱会影响周围冠状动脉组织，并对相邻心肌壁产生音频振动。我们研究了一种使用宽范围门控（WRG）超声数据采集诊断冠状动脉疾病（CAD）的新诊断方法的可行性。WRG数据采集使用脉冲波多普勒超声检测冠状动脉狭窄产生的高频振动。
我们使用Verasonics超声数据采集系统进行WRG数据采集。研究人员对80名疑似CAD的受试者进行了临床试验。所有入选患者在冠状动脉造影（CAG）前均参与了WRG数据采集。
与CAG结果相比，WRG数据分析的敏感性和特异性分别为80%和84%。WRG数据分析显示，在左前降支中敏感性和特异性分别为81%和79%，在左旋支中分别为75%和89%，在右冠状动脉中分别为85%和82%。在多变量分析中，振动测量结果阳性是CAD的独立预测因素。
我们提出了一种使用超声检测CAD的新诊断方法。这种新的数据采集方法作为CAD的初步诊断工具显示出良好的潜力。
