Sato Jun, Yamazaki Yutaka, Satoh Akira, Onodera-Kyan Makiko, Abe Takahiro, Satoh Takehiko, Notani Ken-ichi, Kitagawa Yoshimasa
Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May;111(5):587-92. doi: 10.1016/j.tripleo.2010.11.033.
We have previously reported that the histologic mode of invasion of oral squamous cell carcinoma (OSCC) is a significant risk factor for pain. Here we sought to determine whether pain is a risk factor for poor prognosis in patients with OSCC.
We evaluated the relationships between overall survival rates and clinicopathologic variables, including gender, age, T- and N-stages, pathologic findings, and pain in 109 consecutive patients with untreated OSCC.
Of these 109 patients, 40 (37%) reported spontaneous pain. Univariate analysis showed that the overall survival rates of patients with spontaneous pain was significantly lower than those of patients without pain (P = .002). Multivariate analysis revealed that spontaneous pain and N-stage were significant independent predictors of overall survival rates.
This is the first report showing that spontaneous pain before treatment may be associated with poor prognosis in patients with OSCC.
我们之前曾报道，口腔鳞状细胞癌（OSCC）的组织学浸润方式是疼痛的一个重要危险因素。在此，我们试图确定疼痛是否为OSCC患者预后不良的一个危险因素。
我们评估了109例未经治疗的连续性OSCC患者的总生存率与临床病理变量之间的关系，这些变量包括性别、年龄、T分期和N分期、病理结果以及疼痛情况。
在这109例患者中，40例（37%）报告有自发痛。单因素分析显示，有自发痛患者的总生存率显著低于无疼痛患者（P = .002）。多因素分析表明，自发痛和N分期是总生存率的显著独立预测因素。
这是首份表明治疗前的自发痛可能与OSCC患者预后不良相关的报告。
