抗惊厥药治疗口面部疼痛的疗效：一项系统评价。
The efficacy of anticonvulsants on orofacial pain: a systematic review.
作者信息
Martin Wilhelmus J J M, Forouzanfar Tymour
机构信息
Department of Oral and Maxillofacial Surgery/Oral Pathology, Vrije Universiteit Medical Center/Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 May;111(5):627-33. doi: 10.1016/j.tripleo.2011.01.033.
OBJECTIVE
Controversy exists about the effectiveness of anticonvulsants for the management of orofacial pain disorders. To ascertain appropriate therapies, a systematic review was conducted of existing randomized controlled trials.
STUDY DESIGN
Trials were identified from PubMed, Cochrane, and Ovid Medline databases from 1962 through March 2010, from references in retrieved reports, and from references in review articles. Eight useful trials were identified for this review. Six studies were randomized placebo-controlled trials and 2 studies were randomized active-controlled. Two independent investigators reviewed these articles by using a 15-item checklist.
RESULTS
Four studies were classified as "high quality." However, heterogeneity of the trials and the small sample sizes precluded the drawing of firm conclusions about the efficacy of the interventions studied on orofacial pain patients.
CONCLUSIONS
There is limited to moderate evidence supporting the efficacy of commonly used anticonvulsants for treatment of patients with orofacial pain disorders. More randomized controlled trials are needed on the efficacy of anticonvulsants.
目的
关于抗惊厥药治疗口面部疼痛疾病的有效性存在争议。为确定合适的治疗方法，对现有的随机对照试验进行了系统评价。
研究设计
从1962年至2010年3月的PubMed、Cochrane和Ovid Medline数据库、检索报告中的参考文献以及综述文章中的参考文献中识别试验。本次评价共识别出8项有用的试验。6项研究为随机安慰剂对照试验，2项研究为随机活性对照试验。两名独立研究人员使用一份包含15项内容的清单对这些文章进行了评审。
结果
4项研究被归类为“高质量”。然而，试验的异质性和小样本量妨碍了就所研究的干预措施对口面部疼痛患者的疗效得出确凿结论。
结论
仅有有限至中等程度的证据支持常用抗惊厥药治疗口面部疼痛疾病患者的疗效。需要更多关于抗惊厥药疗效的随机对照试验。
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