Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, University of Rochester, Rochester, NY 14620, USA.
Int J Environ Res Public Health. 2022 May 25;19(11):6443. doi: 10.3390/ijerph19116443.
The aim was to systematically review randomized controlled trials (RCTs) that assessed the effectiveness of curcumin in reducing self-rated pain levels in the orofacial region (OFR). The addressed focused question was "Is curcumin effective in reducing self-rated pain levels in the OFR?". Indexed databases (PubMed (National Library of Medicine), Scopus, EMBASE, MEDLINE (OVID), and Web of Science) were searched up to and including February 2022 using different keywords. The inclusion criteria were (a) original studies (RCTs) in indexed databases; and (b) studies assessing the role of curcumin in the management of pain in the OFR. The risk of bias was assessed using the Cochrane risk of bias tool. The pattern of the present systematic review was customized to primarily summarize the pertinent information. Nineteen RCTs were included. Results from 79% of the studies reported that curcumin exhibits analgesic properties and is effective in reducing self-rated pain associated with the OFR. Three studies had a low risk of bias, while nine and seven studies had a moderate and high risk of bias, respectively. Curcumin can be used as an alternative to conventional therapies in alleviating pain in the OFR. However, due to the limitations and risk of bias in the aforementioned studies, more high-quality RCTs are needed.
目的是系统地回顾评估姜黄素在减轻口腔面部区域（OFR）自我评估疼痛水平方面有效性的随机对照试验（RCT）。提出的聚焦问题是“姜黄素在减轻 OFR 自我评估疼痛水平方面是否有效？”。使用不同的关键字，在截至 2022 年 2 月的范围内，对索引数据库（PubMed（美国国立医学图书馆）、Scopus、EMBASE、MEDLINE（OVID）和 Web of Science）进行了搜索。纳入标准为：（a）索引数据库中的原始研究（RCT）；（b）评估姜黄素在 OFR 疼痛管理中作用的研究。使用 Cochrane 偏倚风险工具评估偏倚风险。本系统评价的模式进行了定制，主要总结相关信息。纳入了 19 项 RCT。79%的研究结果表明，姜黄素具有镇痛作用，可有效减轻与 OFR 相关的自我评估疼痛。三项研究的偏倚风险较低，而九项和七项研究的偏倚风险分别为中度和高度。姜黄素有潜力作为常规疗法的替代方案，用于缓解 OFR 的疼痛。然而，由于上述研究的局限性和偏倚风险，需要更多高质量的 RCT。
