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Neurobiol Aging. 2011 Jul;32(7):1196-7. doi: 10.1016/j.neurobiolaging.2011.02.025. Epub 2011 Apr 16.
The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.
我们对阿尔茨海默病（AD）的表观遗传学进行了回顾，之后的评论强调了一些关键点，包括 1 碳代谢、等位基因特异性甲基化现象、表观遗传机制为全基因组关联和大规模基因表达阵列研究提供的潜在关键解释联系，以及表观遗传修饰在阿尔茨海默病中提供的新治疗方法。
