Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Psychiatry Res. 2011 May 31;192(2):84-90. doi: 10.1016/j.pscychresns.2010.09.001. Epub 2011 Apr 17.
Although limbic structure changes have been found in chronic and recent onset post-traumatic stress disorder (PTSD) patients, there are few studies about brain structure changes in recent onset PTSD patients after a single extreme and prolonged trauma. In the current study, 20 coal mine flood disaster survivors underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) and region of interest (ROI) techniques were used to detect the gray matter and white matter volume changes in 10 survivors with recent onset PTSD and 10 survivors without PTSD. The correlation between the Clinician-Administered PTSD Scale (CAPS) and gray matter density in the ROI was also studied. Compared with survivors without PTSD, survivors with PTSD had significantly decreased gray matter volume and density in left anterior hippocampus, left parahippocampal gyrus, and bilateral calcarine cortex. The CAPS score correlated negatively with the gray matter density in bilateral calcarine cortex and left hippocampus in coal mine disaster survivors. Our study suggests that the gray matter volume and density of limbic structure decreased in recent onset PTSD patients who were exposed to extreme trauma. PTSD symptom severity was associated with gray matter density in calcarine cortex and hippocampus.
虽然在慢性和近期发病的创伤后应激障碍（PTSD）患者中发现了边缘结构的变化，但对于经历单次极端和长期创伤后的近期发病 PTSD 患者的大脑结构变化，研究较少。在目前的研究中，20 名煤矿水灾幸存者接受了磁共振成像（MRI）检查。使用基于体素的形态测量学（VBM）和感兴趣区（ROI）技术，检测 10 名近期发病 PTSD 幸存者和 10 名无 PTSD 幸存者的灰质和白质体积变化。还研究了 CAPS 量表（CAPS）与 ROI 中灰质密度之间的相关性。与无 PTSD 幸存者相比，PTSD 幸存者左侧前海马体、左侧海马旁回和双侧楔前叶皮质的灰质体积和密度明显降低。CAPS 评分与煤矿灾难幸存者双侧楔前叶皮质和左侧海马的灰质密度呈负相关。我们的研究表明，暴露于极端创伤后的近期发病 PTSD 患者的边缘结构灰质体积和密度降低。PTSD 症状严重程度与楔前叶皮质和海马的灰质密度有关。
