Felmingham Kim, Williams Leanne M, Whitford Thomas J, Falconer Erin, Kemp Andrew H, Peduto Anthony, Bryant Richard A
Brain Dynamics Centre, Westmead Millennium Institute, Westmead Hospital, Australia.
Neuroreport. 2009 Oct 28;20(16):1402-6. doi: 10.1097/WNR.0b013e3283300fbc.
To examine the impact of environmental stress on grey matter volume in posttraumatic stress disorder (PTSD), we investigated the relationship between duration of PTSD and grey matter volume of hippocampus and anterior cingulate cortex. Twenty-one participants with PTSD and 17 trauma-exposed controls, matched for age and sex and with no history of substance dependence, underwent a T1-weighted structural MRI scan and voxel-based morphometry was employed. After controlling for age, depression and whole-brain volume, analysis of covariance revealed significant reductions in hippocampus and rostral anterior cingulate cortex in PTSD, and there was a significant negative correlation between right hippocampal volume and PTSD duration. This pattern suggests that prolonged PTSD may have cumulative adverse effects on hippocampal volume, highlighting the potential role of genetic-environmental interactions.
为研究环境压力对创伤后应激障碍（PTSD）患者灰质体积的影响，我们调查了PTSD病程与海马体及前扣带回皮质灰质体积之间的关系。21名患有PTSD的参与者和17名年龄、性别匹配且无物质依赖史的创伤暴露对照者接受了T1加权结构MRI扫描，并采用基于体素的形态学测量方法。在控制了年龄、抑郁和全脑体积后，协方差分析显示PTSD患者的海马体和喙部前扣带回皮质有显著减少，并且右侧海马体体积与PTSD病程之间存在显著负相关。这种模式表明，长期的PTSD可能对海马体体积产生累积不利影响，突出了基因-环境相互作用的潜在作用。
