Department of Pathology, Western Infirmary and University of Glasgow, United Kingdom.
Ann Diagn Pathol. 2011 Oct;15(5):329-32. doi: 10.1016/j.anndiagpath.2011.03.001. Epub 2011 Apr 17.
Fibrosis in the parathyroid glands can be seen in adenomas, in carcinomas, and after fine needle aspiration of the thyroid gland. Fibrosis occurs in approximately 10% of typical adenomas and in all atypical adenomas. This is usually in the form of fibrous bands or trabeculae that intersect the hypercellular parenchyma. However, widespread diffuse fibrosis or sclerosis in either parathyroid gland hyperplasia or adenoma has not been reported before in the English medical literature. We report 3 cases of hyperparathyroidism (2 adenomas and 1 hyperplasia) with an unusual pattern of sclerosis. The hyalinized, eosinophilic fibrous tissue was diffusely distributed within and around the parathyroid parenchyma, often isolating groups of cells and single cells.
甲状旁腺的纤维化可见于腺瘤、癌以及甲状腺细针抽吸后。纤维化发生于约 10%的典型腺瘤和所有非典型腺瘤中。这通常表现为纤维带或小梁穿过细胞丰富的实质。然而，在英文医学文献中，之前并未报道过甲状旁腺增生或腺瘤中弥漫性广泛纤维化或硬化的情况。我们报告了 3 例甲状旁腺功能亢进症（2 例腺瘤和 1 例增生），其硬化模式异常。玻璃样变的嗜酸性纤维组织在甲状旁腺实质内和周围广泛分布，常使细胞群和单个细胞孤立。
